Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal

Frontiers in Microbiology
Filipa Trigo da RozaManuela Oliveira

Abstract

Multidrug-resistant (MDR) Klebsiella pneumoniae is considered a major global concern by the World Health Organization. Evidence is growing on the importance of circulation of MDR bacterial populations between animals and humans. Horses have been shown to carry commensal isolates of this bacterial species and can act as human MDR bacteria reservoirs. In this study, we characterized an extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae sequence type (ST) 348 isolate from a horse, an ST reported for the first time in an animal, using next-generation sequencing. We compared it with six other MDR K. pneumoniae ST348 human isolates previously identified in health-care facilities in Portugal using a core genome multi-locus sequence typing approach to evaluate a possible genetic link. The horse isolate was resistant to most of the antimicrobials tested, including 3rd generation cephalosporins, fluoroquinolones, and aminoglycosides, and presented several antimicrobial resistance genes, including blaESBL. Twenty-one allele differences were found between the horse isolate and the most similar human isolate, suggesting a recent common ancestor. Other similarities were observed regarding the content on antimicrobial resistance gen...Continue Reading

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Citations

Feb 29, 2020·Animals : an Open Access Journal From MDPI·Eddy SukmawinataMasuo Sueyoshi
Feb 26, 2020·Animals : an Open Access Journal From MDPI·Igor LoncaricJoachim Spergser

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BETA
lavages

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BacWGSTdb
Easyfig
Kaptive
Bandage
BLAST
CGE
Unicycler
Kleborate
Abricate
Ridom SeqShere +

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