Communicability distance reveals hidden patterns of Alzheimer's disease

Network Neuroscience
Eufemia Lella, Ernesto Estrada

Abstract

The communicability distance between pairs of regions in human brain is used as a quantitative proxy for studying Alzheimer's disease. Using this distance, we obtain the shortest communicability path lengths between different regions of brain networks from patients with Alzheimer's disease (AD) and healthy cohorts (HC). We show that the shortest communicability path length is significantly better than the shortest topological path length in distinguishing AD patients from HC. Based on this approach, we identify 399 pairs of brain regions for which there are very significant changes in the shortest communicability path length after AD appears. We find that 42% of these regions interconnect both brain hemispheres, 28% connect regions inside the left hemisphere only, and 20% affect vermis connection with brain hemispheres. These findings clearly agree with the disconnection syndrome hypothesis of AD. Finally, we show that in 76.9% of damaged brain regions the shortest communicability path length drops in AD in relation to HC. This counterintuitive finding indicates that AD transforms the brain network into a more efficient system from the perspective of the transmission of the disease, because it drops the circulability of the dis...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Nov 1, 1982·Journal of the Neurological Sciences·G K Wilcock, M M Esiri
Dec 17, 1998·Trends in Cell Biology·E M Mandelkow, E Mandelkow
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jul 31, 2003·Neuropsychology Review·X DelbeuckF Collette
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada, Juan A Rodríguez-Velázquez
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada, Naomichi Hatano
Jan 2, 2009·Stroke; a Journal of Cerebral Circulation·Panteleimon GiannakopoulosConstantin Bouras
Jan 15, 2009·Journal of the Royal Society, Interface·Jonathan J Crofts, Desmond J Higham
Nov 17, 2009·Frontiers in Human Neuroscience·Suzana Herculano-Houzel
Dec 2, 2010·Frontiers in Systems Neuroscience·Heidi Johansen-BergCharlotte J Stagg
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun-Yi LoChing-Po Lin
Oct 27, 2011·Annals of Neurology·Mathias Jucker, Lary C Walker
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Mar 27, 2012·Neuron·Ashish RajMichael Weiner
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada
Jul 24, 2013·Trends in Neurosciences·Jason D WarrenMartin N Rossor
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dardo TomasiNora D Volkow
Nov 19, 2013·Trends in Cognitive Sciences·Mikail Rubinov, Ed Bullmore
Sep 5, 2014·Nature Reviews. Neuroscience·Cornelis J Stam
Sep 6, 2014·Frontiers in Human Neuroscience·Marcel A de Reus, Martijn P van den Heuvel
Oct 14, 2014·Frontiers in Neural Circuits·William M DeBelloDouglas J Totten
Nov 21, 2014·PLoS Computational Biology·Yasser Iturria-MedinaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 16, 2015·Nature Reviews. Neuroscience·Johannes BrettschneiderJohn Q Trojanowski
Apr 4, 2015·Annual Review of Neuroscience·Lary C Walker, Mathias Jucker
Aug 16, 2016·NeuroImage·Jelle VeraartEls Fieremans
Feb 24, 2017·Nature Neuroscience·Danielle S Bassett, Olaf Sporns
Oct 21, 2017·Brain : a Journal of Neurology·Heidi I L JacobsJeremy D Schmahmann
May 26, 2018·Nature·Mauricio González-Forero, Andy Gardner
May 26, 2018·PLoS Computational Biology·Lazaro M Sanchez-RodriguezUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Caio SeguinAndrew Zalesky
Jun 8, 2018·NeuroImage. Clinical·Peter N TaylorJohn S Duncan
Sep 2, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Ashish Raj, Fon Powell
Sep 28, 2018·Network Neuroscience·Enrico Amico, Joaquín Goñi

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Citations

Nov 17, 2020·Network Neuroscience·Daniel GrahamBratislav Mišić

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