Communication: Activation energy of tension-induced pore formation in lipid membranes

The Journal of Chemical Physics
Mohammad Abu Sayem Karal, Masahito Yamazaki

Abstract

Tension plays a vital role in pore formation in biomembranes, but the mechanism of pore formation remains unclear. We investigated the temperature dependence of the rate constant of constant tension (σ)-induced pore formation in giant unilamellar vesicles of lipid membranes using an experimental method we developed. By analyzing this result, we determined the activation energy (Ua) of tension-induced pore formation as a function of tension. A constant (U0) that does not depend on tension was found to contribute significantly to Ua. Analysis of the activation energy clearly indicated that the dependence of Ua on σ in the classical theory is correct, but that the classical theory of pore formation is not entirely correct due to the presence of U0. We can reasonably consider that U0 is a nucleation free energy to form a hydrophilic pre-pore from a hydrophobic pre-pore or a region with lower lateral lipid density. After obtaining U0, the evolution of a pre-pore follows a classical theory. Our data provide valuable information that help explain the mechanism of tension-induced pore formation in biomembranes and lipid membranes.

References

Oct 21, 1975·Biochemistry·C TaupinC Sauterey
May 24, 1988·Biochimica Et Biophysica Acta·R W GlaserA I Sokirko
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·O SandreF Brochard-Wyart
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
Mar 1, 2003·Biophysical Journal·Erdem KaratekinFrançoise Brochard-Wyart
Sep 26, 2003·Biophysical Journal·Evan EvansWieslawa Rawicz
Oct 20, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Tomoki TanakaMasahito Yamazaki
Oct 29, 2005·The Journal of Chemical Physics·Zun-Jing Wang, Daan Frenkel
May 6, 2006·The Journal of Chemical Physics·J WohlertW J Briels
Oct 4, 2011·New Journal of Physics·Evan Evans, Benjamin A Smith
Mar 12, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Victor LevadnyMasahito Yamazaki
Aug 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mohammad Abu Sayem KaralMasahito Yamazaki

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Citations

Jan 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Apr 30, 2016·Physical Chemistry Chemical Physics : PCCP·Mohammad Abu Sayem KaralMasahito Yamazaki
Mar 29, 2019·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralMd Mostofa Shakil
Sep 26, 2019·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralKhondkar Siddique-E-Rabbani
Dec 5, 2019·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralZaid Bin Mahbub
Feb 20, 2020·Physical Review. E·Mohammad Abu Sayem KaralMd Mostofa Shakil
May 31, 2020·Journal of Fluorescence·Mohammad Abu Sayem KaralZaid Bin Mahbub
Jun 15, 2020·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralShareef Ahammed
Aug 11, 2020·The Journal of Chemical Physics·Mayank Dixit, Themis Lazaridis
Jul 2, 2018·The Journal of Chemical Physics·Moynul HasanMasahito Yamazaki
Jun 5, 2020·European Biophysics Journal : EBJ·Md Kabir AhamedShareef Ahammed
Aug 1, 2019·The Journal of Membrane Biology·Edel Cunill-Semanat, Jesús Salgado
May 15, 2021·PloS One·Malay Kumar SarkarSayed Ul Alam Shibly
Aug 8, 2018·The Journal of Physical Chemistry Letters·Sean BurgessAlexander V Neimark
Jun 17, 2020·The Journal of Physical Chemistry. B·Samiron Kumar SahaMasahito Yamazaki
Jan 25, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Orrin ShindellVernita D Gordon

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