Communication: Rigidification of a lipid bilayer by an incorporated n-alkane

The Journal of Chemical Physics
Mafumi HishidaKazuya Saito

Abstract

Towards a greater understanding of the effects of organic molecules in biomembranes, the effects of a flexible alkyl chain on the morphologies of phospholipid vesicles are investigated. Vesicles composed of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine and tetradecane (TD) rupture during cooling from the liquid-crystalline phase to the gel phase. A model calculation based on the size-dependent rupture probability indicates that the bending rigidity of the bilayer in the gel phase is more than 10 times higher than that without TD, resulting in the rupture arising from elastic stress. The rigidification is caused by the denser molecular packing in the hydrophobic region by TD. There is little change of the rigidity in the liquid-crystalline phase. Additionally, the rigidification produces a characteristic morphology of the ternary giant vesicles including TD. Reported thermal behaviors imply that molecules with a linear and long alkyl chain, such as trans fatty acids, universally exhibit a similar effect, in contrast to rigid and bulky molecules, such as cholesterol.

References

Mar 25, 1977·Biochimica Et Biophysica Acta·S Mabrey, J M Sturtevant
Mar 1, 1991·Chemistry and Physics of Lipids·K Lohner
Apr 24, 1980·Biochimica Et Biophysica Acta·T J McIntoshR C MacDonald
Jun 5, 1997·Nature·K Simons, E Ikonen
Nov 7, 2000·Biochimica Et Biophysica Acta·J F Nagle, S Tristram-Nagle
Aug 11, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·C H LeeJ Wang
Jun 14, 2005·Biophysical Journal·Mary Elizabeth BeattieSarah L Keller
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Gang Ma, Heather C Allen
May 28, 2008·The Journal of Physical Chemistry. B·Narayanan SrividyaBrian Tripp
Mar 29, 2014·Advances in Colloid and Interface Science·Rumiana Dimova
May 11, 2015·Chemistry and Physics of Lipids·Mafumi HishidaKazuya Saito

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Citations

May 25, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Hatsuho UsudaKazuya Saito
Dec 14, 2016·The Journal of Physical Chemistry. B·Remco HartkampClare McCabe
Jan 7, 2020·Physical Chemistry Chemical Physics : PCCP·Hatsuho UsudaKazuya Saito
Dec 22, 2020·Structural Dynamics·Michihiro NagaoChristopher L Kitchens
Jan 24, 2020·Biochimica Et Biophysica Acta. Biomembranes·Adrian Paz RamosMichel Lafleur
Nov 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Mafumi HishidaKazuya Saito
Mar 21, 2020·The Journal of Physical Chemistry. B·Alexander YangClare McCabe

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