Community-acquired bacteremia among children admitted to a rural hospital in Mozambique

The Pediatric Infectious Disease Journal
Betuel SigaúquePedro L Alonso

Abstract

Although community-acquired bacteremia is an important cause of childhood mortality in Africa, recognition of disease burden and potential impact of bacterial vaccines is limited. Blood cultures for bacterial pathogens were conducted systematically among children <15 years of age admitted to Manhiça District Hospital, from 2001 to 2006. Blood-stream infections were identified in 8% (1550/19,896) of pediatric hospital admissions. Nontyphoidal Salmonella (NTS) and Pneumococcus were the most prevalent pathogens isolated (26% and 25% of 1550 cases, respectively). Until 28 days of life, Staphylococcus aureus (39%) and group B Streptococcus (20%) predominated. Incidence of community-acquired bacteremia per 100,000 child-years was 1730/10 in children <1 year old, 782/10 in 1-4 year oldd, and 49/10 in children 5 years and older. Case-fatality of bacteremia was 12%. Community-acquired bacteremia associated mortality accounted for 21% (162/788) of hospital deaths. Resistance to antibiotics commonly used in Mozambique was high among invasive isolates of Haemophilus influenzae, Escherichia coli, and NTS. Community-acquired bacteremia is an important cause of pediatric hospital admission and death in rural African hospitals. The high burden...Continue Reading

References

Jan 1, 1992·Annals of Tropical Paediatrics·I R Friedland
Apr 1, 1996·The Pediatric Infectious Disease Journal·W A BanyaB M Greenwood
Dec 1, 1996·The American Journal of Tropical Medicine and Hygiene·J R ZuckerC C Campbell
Apr 27, 2000·The Pediatric Infectious Disease Journal·A L WalshM E Molyneux
Feb 13, 2002·The Pediatric Infectious Disease Journal·Maria P LoscertalesPedro L Alonso
Apr 16, 2002·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·P BahwereP De Mol
Oct 3, 2003·The New England Journal of Medicine·Keith P KlugmanUNKNOWN Vaccine Trialists Group
Feb 12, 2004·The Pediatric Infectious Disease Journal·Elizabeth B NortonJanine Jason
Jan 7, 2005·The New England Journal of Medicine·James A BerkleyJ Anthony G Scott
Jan 7, 2005·The New England Journal of Medicine·E Kim Mulholland, Richard A Adegbola
Mar 30, 2005·Lancet·Jennifer BryceUNKNOWN WHO Child Health Epidemiology Reference Group
Jul 19, 2005·Lancet·Stephen HowieTumani Corrah
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Francisco SaútePedro Alonso
Aug 26, 2006·Tropical Medicine & International Health : TM & IH·A RocaP Alonso
Jan 30, 2007·BMC Infectious Diseases·Philip C HillRichard A Adegbola

❮ Previous
Next ❯

Citations

Oct 2, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Behzad NadjmChristopher J M Whitty
Feb 1, 2013·The New England Journal of Medicine·Indi TrehanMark J Manary
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Esther N GondweCalman A MacLennan
Jul 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan C MorpethJohn A Crump
Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A CrumpVenance P Maro
Apr 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alemnew F DagnewSue Ann Costa Clemens
Apr 30, 2009·Journal of Tropical Pediatrics·Betuel SigaúquePedro L Alonso
Jan 28, 2010·The Pediatric Infectious Disease Journal·Olivier VandenbergFrank M Aarestrup
Jul 30, 2011·The Pediatric Infectious Disease Journal·Peter NyasuluUNKNOWN Group for Enteric, Respiratory and Meningeal Diseases Surveillance in South Africa (GERMS-SA)
Aug 17, 2011·Current Opinion in Infectious Diseases·Melita A Gordon
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Feb 24, 2011·Infection and Immunity·Renée M TsolisAndreas J Bäumler
Nov 26, 2010·Journal of Clinical Microbiology·T WereD J Perkins
May 21, 2011·BMC Infectious Diseases·Stephen ObaroRichard Adegbola
Mar 3, 2010·PloS One·Clara MenéndezPedro L Alonso
Sep 13, 2012·PloS One·Maja Verena NielsenNorbert Georg Schwarz
Jan 10, 2014·PloS One·Ana Herrero-FresnoRene S Hendriksen
Aug 26, 2010·Emerging Infectious Diseases·Nicholas A FeaseyKaren H Keddy
Oct 18, 2011·Emerging Infectious Diseases·Katherine J GrayNeil French
Nov 6, 2013·Emerging Infectious Diseases·Oleg MediannikovDidier Raoult
Jul 3, 2013·The American Journal of Tropical Medicine and Hygiene·Behzad NadjmHugh Reyburn
Jul 3, 2010·The American Journal of Tropical Medicine and Hygiene·Inácio MandomandoPedro L Alonso
Dec 21, 2012·Future Microbiology·Mathias HerrmannMartin P Grobusch
Aug 27, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M-F PhobaJ Jacobs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

The New England Journal of Medicine
James A BerkleyJ Anthony G Scott
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Melita A GordonMalcolm E Molyneux
The American Journal of Tropical Medicine and Hygiene
Inacio MandomandoPedro L Alonso
The Pediatric Infectious Disease Journal
A L WalshMalcolm E Molyneux
© 2021 Meta ULC. All rights reserved