Community-acquired bacterial meningitis in adults with cancer or a history of cancer

Neurology
Joost M CosterusDiederik van de Beek

Abstract

To study the incidence, clinical presentation, causative bacteria, and outcome of community-acquired bacterial meningitis in adults with cancer. We evaluated incidence and characteristics of patients with cancer included in a nationwide prospective cohort study of adults with community-acquired meningitis performed in the Netherlands from March 1, 2006, to September 31, 2014. All patients underwent a neurologic examination at hospital discharge, and outcome was graded using the Glasgow Outcome Scale. Active cancer was identified in 68 of 1,351 episodes (5%) and a history of cancer in 87 (6%). The annual incidence of community-acquired bacterial meningitis was 2.71-fold (95% confidence interval [CI] 1.68-4.36, p < 0.001) increased for patients with cancer compared to patients without cancer in 2010, and 3.52-fold (95% CI 2.16-5.73, p < 0.001) in 2013. The clinical presentation of bacterial meningitis in patients with cancer compared to patients without cancer was similar. Patients with active cancer presented with lower leukocyte count in blood (12.1 × 10(9) cells/L vs 17.3 × 10(9) cells/L, p < 0.001) and CSF (670 cells/mm(3) vs 2,567 cells/mm(3), p < 0.001) and were more likely to be infected with Listeria monocytogenes (21% vs...Continue Reading

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Citations

Aug 4, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J M CosterusD van de Beek
Nov 4, 2016·Nature Reviews. Disease Primers·Diederik van de BeekEelco Wijdicks
Nov 7, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S P DiasD van de Beek
Mar 18, 2017·Infectious Diseases·Lene Fogt Lundbo, Thomas Benfield
Sep 1, 2018·Journal of Neuropathology and Experimental Neurology·Joo-Yeon Engelen-LeeDiederik van de Beek
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Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Amy A Pruitt
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin GlimåkerPontus Naucler
Sep 17, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A H A FigueiredoD van de Beek
May 27, 2021·Current Neurology and Neuroscience Reports·Amy A Pruitt

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