Abstract
To study the incidence, clinical presentation, causative bacteria, and outcome of community-acquired bacterial meningitis in adults with cancer. We evaluated incidence and characteristics of patients with cancer included in a nationwide prospective cohort study of adults with community-acquired meningitis performed in the Netherlands from March 1, 2006, to September 31, 2014. All patients underwent a neurologic examination at hospital discharge, and outcome was graded using the Glasgow Outcome Scale. Active cancer was identified in 68 of 1,351 episodes (5%) and a history of cancer in 87 (6%). The annual incidence of community-acquired bacterial meningitis was 2.71-fold (95% confidence interval [CI] 1.68-4.36, p < 0.001) increased for patients with cancer compared to patients without cancer in 2010, and 3.52-fold (95% CI 2.16-5.73, p < 0.001) in 2013. The clinical presentation of bacterial meningitis in patients with cancer compared to patients without cancer was similar. Patients with active cancer presented with lower leukocyte count in blood (12.1 × 10(9) cells/L vs 17.3 × 10(9) cells/L, p < 0.001) and CSF (670 cells/mm(3) vs 2,567 cells/mm(3), p < 0.001) and were more likely to be infected with Listeria monocytogenes (21% vs...Continue Reading
References
May 15, 1976·Lancet·B JennettR Knill-Jones
Jul 1, 1977·Cancer·N L ChernikJ B Posner
Nov 1, 1973·Medicine·N L ChernikJ B Posner
Mar 1, 1984·Neurology·S A LukesD Armstrong
Dec 14, 2001·The New England Journal of Medicine·R HasbunV J Quagliarello
Mar 27, 2002·Nature Reviews. Immunology·Steve Nelson, Jay K Kolls
Jul 29, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C R HuangW N Chang
Jan 13, 2004·Cancer·Jeffrey CrawfordGary H Lyman
Oct 29, 2004·The New England Journal of Medicine·Diederik van de BeekMarinus Vermeulen
Jul 5, 2005·The Journal of Infectious Diseases·Moe H KyawUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L M A J MullerG E H M Rutten
Jan 6, 2006·The New England Journal of Medicine·Diederik van de BeekEelco F M Wijdicks
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthijs C BrouwerJan de Gans
Feb 19, 2008·The British Journal of Surgery·E G MourtzoukouM E Falagas
Mar 19, 2008·Neurology·J E SafdiehL E Abrey
Dec 2, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Coralia N MihuGenovefa A Papanicolaou
Mar 14, 2009·Medicine·Carmen CabellosPedro F Viladrich
Jan 15, 2010·The New England Journal of Medicine·Diederik van de BeekAllan R Tunkel
Mar 26, 2010·The Lancet Infectious Diseases·Matthijs C BrouwerDiederik van de Beek
Jun 25, 2010·American Journal of Epidemiology·Casper RoedNiels Obel
Jan 18, 2011·Hematology/oncology Clinics of North America·John R WingardJohn W Hiemenz
Nov 1, 2011·The Journal of Infection·Casper RoedNiels Obel
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Amy A Pruitt
Nov 10, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Lindsey Robert BadenUNKNOWN National Comprehensive Cancer Network
Nov 13, 2012·Lancet·Matthijs C BrouwerDiederik van de Beek
Apr 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Merel M KoopmansDiederik van de Beek
May 1, 2013·Mayo Clinic Proceedings·Kirsten S AdrianiDiederik van de Beek
Apr 8, 2014·Cancer Treatment and Research·Michael J Hoffman, Valentina Stosor
Dec 3, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christine RobinCatherine Cordonnier
Citations
Aug 4, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J M CosterusD van de Beek
Nov 4, 2016·Nature Reviews. Disease Primers·Diederik van de BeekEelco Wijdicks
Nov 7, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S P DiasD van de Beek
Mar 18, 2017·Infectious Diseases·Lene Fogt Lundbo, Thomas Benfield
Sep 1, 2018·Journal of Neuropathology and Experimental Neurology·Joo-Yeon Engelen-LeeDiederik van de Beek
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Larry E Davis
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Amy A Pruitt
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin GlimåkerPontus Naucler
May 11, 2017·Medicine·Virginia PomarPere Domingo
Jul 16, 2020·Acta neurologica Belgica·I SmetsB Dubois
Sep 17, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A H A FigueiredoD van de Beek
May 27, 2021·Current Neurology and Neuroscience Reports·Amy A Pruitt