Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis

Surgical Infections
Lisa M Young, Connie S Price

Abstract

Necrotizing fasciitis (NF) is an uncommon fulminant soft tissue infection characterized by extensive fascial necrosis. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates producing the Panton-Valentine leukocidin (PVL) cytotoxin have been associated with serious necrotizing infections, but NF caused by CA-MRSA has been described only recently. We reviewed our NF experience at Denver Health Medical Center, where CA-MRSA accounts for more than 50% of community S. aureus clinical isolates. Patients treated for NF from January 2004 to February 2006 were identified by review of pathology records and diagnostic codes, and their medical records were reviewed. Isolates of MRSA from monomicrobial NF underwent testing for the PVL gene and pulsed-field gel electrophoresis to determine relatedness to CA-MRSA strains. Five of 30 NF cases during the study period, all involving the extremities, were caused by MRSA. Monomicrobial MRSA NF accounted for three cases, with all of the patients reporting a distinct "spider bite" lesion 2-3 days prior to admission. The median age was 32 years (range 28-55 years). Resistance to erythromycin and levofloxacin was present in four isolates. None of the isolates displayed indu...Continue Reading

References

Oct 1, 1980·Annals of Internal Medicine·J E PeacockR P Wenzel
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G LinaJ Etienne
Aug 10, 2000·American Journal of Surgery·D ElliottR A Myers
Jul 1, 2004·The Journal of the American Board of Family Practice·Tamara J Dominguez
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John S FrancisJohn G Bartlett
Apr 9, 2005·The New England Journal of Medicine·Loren G MillerBrad Spellberg

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Citations

Mar 5, 2011·Der Unfallchirurg·M HerrC Willy
Jul 29, 2011·Current Infectious Disease Reports·Marina S Morgan
Apr 9, 2010·Surgical Infections·Lena M Napolitano
Mar 27, 2009·Journal of Clinical Microbiology·Brandi LimbagoUNKNOWN Active Bacterial Core surveillance MRSA Investigators
Nov 28, 2012·Chirurgie de la main·A Forli
Jan 6, 2016·The Indian Journal of Surgery·Gurjit SinghRaghuveer Reddy
Jun 15, 2010·The Journal of Hospital Infection·M S Morgan
Dec 17, 2009·Journal of Surgical Education·Shaun R BrownKurt G Davis
Nov 17, 2009·Infectious Disease Clinics of North America·Stephen WeberDonald Kaye
Aug 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·J Aragón-SánchezJ V Beneit-Montesinos
May 18, 2012·Dermatologic Therapy·Brittany SambranoNoah Scheinfeld
Jul 19, 2012·The British Journal of Dermatology·M DemosK Nouri
Jul 15, 2015·Journal of Infection and Public Health·Dipendra ThapaliyaTara C Smith
Sep 29, 2015·Journal of the American Academy of Dermatology·Camille HuaOlivier Chosidow
Sep 8, 2010·Annals of Emergency Medicine·Karen M RogersDonna Seger
Apr 5, 2017·Surgical Infections·Christine S CocanourMatthew R Rosengart
Jun 13, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K O OriiT Yamamoto
Aug 28, 2010·Critical Care Medicine·Ho H Phan, Christine S Cocanour
May 3, 2011·Critical Care Medicine·Jeffrey S Ustin, Mark A Malangoni
Mar 17, 2011·Annals of Plastic Surgery·Nai-Chen ChengYueh-Bih Tang
Mar 7, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Joseph M BellapiantaRichard Uhl
Aug 16, 2017·Journal of Community Hospital Internal Medicine Perspectives·Jeffrey A Freiberg
Apr 23, 2020·Surgical Infections·Hannah Zhao-FlemingSharmila Dissanaike
Aug 8, 2021·Surgery·Chathurika S DhanasekaraSharmila Dissanaike

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