Community-acquired Methicillin-resistant Staphylococcus aureus Musculoskeletal Infections: Emerging Trends Over the Past Decade

Journal of Pediatric Orthopedics
Eric J SarkissianJohn M Flynn

Abstract

The emergence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has altered the management of pediatric musculoskeletal infections. Yet, institution-to-institution differences in MRSA virulence may exist, suggesting a need to carefully examine local epidemiological characteristics. The purpose of this study was to compare MRSA and methicillin-sensitive S. aureus (MSSA) musculoskeletal infections with respect to prevalence and complexity of clinical care over the past decade at a single children's hospital. We retrospectively reviewed a series of patients presenting to The Children's Hospital of Philadelphia with a diagnosis of osteomyelitis, septic arthritis, or both over a 10-year period. Inclusion criteria were S. aureus (SA) infections proven by positive culture of blood, bone, or joint aspirate. Exclusion criteria were non-SA infectious etiologies. Hospital-acquired infections were also not included to exclusively evaluate acute, community-acquired cases. Data related to hospital course, laboratory values, and number of surgical interventions were collected and compared between MRSA and MSSA cohorts. In our series of pediatric patients, we identified 148 cases of acute, community-acquired musculoskele...Continue Reading

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Citations

Mar 15, 2016·Expert Review of Proteomics·Kelly M FultonSusan M Twine
Jul 29, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Alexandre ArkaderKenneth Noonan
Sep 10, 2018·BMJ Case Reports·Teresa Pena FernandesAugusto Ribeiro
Oct 16, 2016·Journal of Pediatric Orthopedics·Alexander G AtheyLawson A Copley
Jun 5, 2020·PloS One·Jonathan G Schoenecker, UNKNOWN Children’s Orthopaedic Trauma and Infection Consortium for Evidence Based Study (CORTICES) Group
Jul 9, 2020·The Pediatric Infectious Disease Journal·John S BradleyMekki Bensaci
Jul 2, 2019·Pediatric Emergency Care·Michael GottliebMelissa Rice
Jul 23, 2019·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Gabriella SafdiehEmily R Dodwell
Feb 28, 2020·JBJS Reviews·Ishaan SwarupKeith D Baldwin
Mar 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng-Yang ChenFang Zhou

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