Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management

Diagnostic Microbiology and Infectious Disease
Lauge FarnaesNicole G Coufal

Abstract

Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now targets the most likely pathogen(s), including those that may demonstrate significant antibiotic resistance. Cell-free plasma next-generation sequencing (CFPNGS) was first made available for Pediatric Infectious Diseases physicians in June 1, 2017, to supplement standard-of-care diagnostic techniques. A retrospective chart review was performed for children hospitalized with CAP between June 1, 2017, and January 22, 2018, to evaluate the impact of CFPNGS. We identified 15 hospitalized children with CAP without other underlying medical conditions for whom CFPNGS was performed. CFPNGS identified a pathogen in 13 of 15 (86%) children compared with 47% for those using standard culture and PCR-based methods alone. Changes in antibiotic management were made in 7 of 15 (47%) of children as a result of CFPNGS.

Citations

Jan 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine A HoganNiaz Banaei
Sep 13, 2019·Journal of Clinical Microbiology·Kanagavel MurugesanNiaz Banaei
Jun 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A BrandaNira R Pollock
Aug 30, 2020·Hospital Pediatrics·Sonya C Tang GirdwoodCatherine S Forster
Apr 25, 2020·Scientific Reports·Sara L Rassoulian BarrettStephen J Salipante
Sep 4, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Xu ChenHong Luo
Sep 24, 2020·Journal of the Pediatric Infectious Diseases Society·Betial AsmeromNanda Ramchandar
Jun 18, 2020·Case Reports in Obstetrics and Gynecology·Irene A StaffordKenneth Muldrew
Jan 8, 2021·The Pediatric Infectious Disease Journal·Rachel K ToNicole G Coufal
Dec 25, 2021·Journal of the Pediatric Infectious Diseases Society·Priya Edward, Andrew S Handel
Dec 1, 2021·The Pediatric Infectious Disease Journal·Denver T NilesDebra L Palazzi
Dec 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Heather K LehmanKimberly A Risma

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Methods Mentioned

BETA
PCR

Software Mentioned

Bowtie2
REDCap
CFPNGS
NCBI
blast
bcl2fastq

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