Community-Acquired Pneumonia Patients at Risk for Early and Long-term Cardiovascular Events Are Identified by Cardiac Biomarkers

Chest
Rosario MenéndezAntoni Torres

Abstract

Community-acquired pneumonia (CAP) increases the risk of cardiovascular complications during and following the episode. The goal of this study was to determine the usefulness of cardiovascular and inflammatory biomarkers for assessing the risk of early (within 30 days) or long-term (1-year follow-up) cardiovascular events. A total of 730 hospitalized patients with CAP were prospectively followed up during 1 year. Cardiovascular (proadrenomedullin [proADM], pro-B-type natriuretic peptide (proBNP), proendothelin-1, and troponin T) and inflammatory (interleukin 6 [IL-6], C-reactive protein, and procalcitonin) biomarkers were measured on day 1, at day 4/5, and at day 30. Ninety-two patients developed an early event, and 67 developed a long-term event. Significantly higher initial levels of proADM, proendothelin-1, troponin, proBNP, and IL-6 were recorded in patients who developed cardiovascular events. Despite a decrease at day 4/5, levels remained steady until day 30 in those who developed late events. Biomarkers (days 1 and 30) independently predicted cardiovascular events adjusted for age, previous cardiac disease, Pao2/Fio2 < 250 mm Hg, and sepsis: ORs (95% CIs), proendothelin-1, 2.25 (1.34-3.79); proADM, 2.53 (1.53-4.20); proB...Continue Reading

Citations

Jan 30, 2020·Medical Sciences : Open Access Journal·Catia CillónizAntoni Torres
Feb 23, 2020·Journal of Clinical Medicine·Raúl MéndezRosario Menéndez
Oct 10, 2020·Expert Review of Anti-infective Therapy·Alexander RombautsJordi Carratalà
Dec 19, 2020·Expert Review of Respiratory Medicine·Yu SongXiaomin Liu
Feb 13, 2021·The European Respiratory Journal·Martin Kolditz, Tobias Welte
Apr 22, 2020·Journal of Cardiac Failure·Gregorio TersalviDario Winterton
Sep 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hector F AfricanoLuis F Reyes
May 18, 2021·Current Problems in Cardiology·Shahzad KhanSyed Imran Ahmed
Jun 5, 2021·British Journal of Clinical Pharmacology·Roberto CangemiUNKNOWN SIXTUS study group
Jul 10, 2021·Annals of the American Thoracic Society·Charles S Dela CruzRichard G Wunderink
Sep 21, 2021·Biomarkers in Medicine·Tahani TabassumMohammad J Hosen
Oct 6, 2021·Thorax·Raúl MéndezRosario Menéndez

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