Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water

Environmental Health Perspectives
M ArayaR Uauy

Abstract

We assessed gastrointestinal effects in 1,365 adults exposed to either < 0.01 (controls), 2, 4, or 6 mg copper/L of drinking water for 2 months in a randomized, double-blind community-based study. The risk of symptoms increased with increasing Cu exposure and decreased with time. The best model by counting-process analysis included Cu concentration and sex. The risk of symptoms remained significantly higher in women than in men during weeks 1-4 for all concentrations tested; at week 1 comparison with the < 0.01-mg/L group showed that differences became significant in women at 4 mg/L [relative risk (RR) = 1.53; 95% confidence interval (CI), 1.02-2.05), and in men at 6 mg/L (RR = 1.9; 95% CI, 1.02-2.79). At week 2 for men and week 4 in women, the Cu concentration required to obtain significant differences on symptom report was > 6 mg Cu/L. We conclude that exposure to Cu in drinking water results in gastrointestinal symptoms, which are modulated by Cu concentration, time, and sex.

References

May 20, 1998·The American Journal of Clinical Nutrition·I Bremner
May 20, 1998·The American Journal of Clinical Nutrition·D J Fitzgerald
Aug 1, 1998·Journal of the Autonomic Nervous System·N Furukawa, M Hatano
Nov 1, 1994·Environmental Health Perspectives·L KnobelochM Proctor
Jan 29, 1999·Environmental Health Perspectives·F PizarroV Gidi
May 26, 1999·Environmental Health Perspectives·R Pettersson, F Rasmussen
Jun 16, 2001·Regulatory Toxicology and Pharmacology : RTP·M OlivaresR Uauy
Sep 29, 2001·Digestive Diseases and Sciences·M GottelandM Olivares
Oct 18, 2001·Regulatory Toxicology and Pharmacology : RTP·M ArayaK A Poirier
Jan 16, 2003·The Science of the Total Environment·Björn P ZietzHartmut Dunkelberg
Feb 1, 1951·The American Journal of Physiology·S C WANG, H L BORISON

❮ Previous
Next ❯

Citations

Dec 8, 2004·Environmental Health Perspectives·Marco A MéndezMauricio González
Jul 25, 2007·Biological Trace Element Research·Fernando PizarroRicardo Uauy
Jan 18, 2008·Journal of Medical Primatology·H NúñezM Olivares
Feb 22, 2017·Environmental Science and Pollution Research International·Jia-Dong ChenRu-An Chi
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Somdat MahabirMichele R Forman
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Bonnie Ransom Stern
Dec 21, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Andrea ChambersWout Slob
Aug 3, 2017·International Journal of Public Health·Rebeca de Jesus Crespo, Richard Fulford
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·H Barton
Aug 18, 2009·Biological Trace Element Research·Miguel ArredondoMagdalena Araya
Sep 6, 2017·Materials·Ignacio T VargasGonzalo E Pizarro
Jun 17, 2006·The Tohoku Journal of Experimental Medicine·Nurullah GunayIsmail Togun
Jun 16, 2016·Journal of Health & Pollution·Sandra CortésCatterina Ferreccio
Mar 22, 2021·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A BocquetUNKNOWN Comité de nutrition de la Société française de pédiatrie (CN-SFP)
Aug 23, 2005·Molecular Aspects of Medicine·Janet Y Uriu-Adams, Carl L Keen
Feb 24, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Daniel López de RomañaMagdalena Araya

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic absorption

Software Mentioned

Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
M SchwartzK Griffith
© 2022 Meta ULC. All rights reserved