Community cohort study of rotavirus and other enteropathogens: are routine vaccinations associated with sex-differential incidence rates?

Vaccine
Amabelia RodriguesPeter Aaby

Abstract

Community studies in West Africa have demonstrated that routine vaccinations may have non-targeted effects, the female-male mortality ratio being reduced after administration of BCG and increased after diphtheria-tetanus-pertussis (DTP). We examined whether immunisation status was associated with infection with rotavirus and other enteropathogens. We recruited 200 children shortly after birth and followed them until 2 years of age with weekly morbidity interviews and stool sampling. Vaccination status for each child was classified according to the most recent vaccination as documented by vaccination card. The female-male incidence rate ratios (IRR) of infection with an enteropathogen and of enteropathogen-associated diarrhoea were estimated for children according to whether they had received BCG or DTP as their last vaccination. For children who received BCG as their last vaccine, the adjusted female-male IRRs for primary rotavirus-infection and diarrhoea were 1.05 (95% CI: 0.21-5.28) and 0.0 (95% CI: 0-3.02), respectively. For children who received DTP as their last vaccine, the adjusted female-male IRRs were 1.93 (0.89-4.21) and 1.92 (0.70-5.32), respectively, for rotavirus-associated infection and diarrhoea. Restricted to th...Continue Reading

Citations

Jul 16, 2011·Journal of Tropical Medicine·Mogens Helweg Claesson
May 6, 2011·International Journal of Epidemiology·Signe SørupAdam Roth
Nov 26, 2009·The Pediatric Infectious Disease Journal·Peter AabyChristine S Benn
May 2, 2007·Current Opinion in Infectious Diseases·Jim P Buttery, Carl Kirkwood
May 12, 2015·Vaccine·Sarah PrenticeUNKNOWN MRC-International Nutrition Group
Aug 22, 2009·The Lancet Infectious Diseases·Elisabeth Sanchez-PadillaFrancisco J Luquero
Mar 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bastiaan A BlokMihai G Netea
Jul 8, 2015·Journal of Leukocyte Biology·Bastiaan A BlokMihai G Netea
Dec 20, 2018·Frontiers in Immunology·Deeva UthayakumarKarelle De Luca
Feb 26, 2021·Human Vaccines & Immunotherapeutics·Ryoko Sato

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