Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda

PLoS Neglected Tropical Diseases
Benjamin G JacobT R Unnasch

Abstract

Onchocerciasis a neglected tropical disease that historically has been a major cause of morbidity and an obstacle to economic development in the developing world. It is caused by infection with Onchocerca volvulus, which is transmitted by black flies of the genus Simulium. The discovery of the potent effect of Mectizan (ivermectin) on O. volvulus microfilariae and the decision by its manufacturer to donate the drug for onchocerciasis spurred the implementation of international programs to control and, more recently, eliminate this scourge. These programs rely primarily on mass distribution of ivermectin (MDA) to the afflicted populations. However, MDA alone will not be sufficient to eliminate onchocerciasis where transmission is intense and where ivermectin MDA is precluded by co-endemicity with Loa loa. Vector control will likely be required as a supplemental intervention in these situations. Because biting by the black fly vectors is often a major nuisance in onchocerciasis afflicted communities, we hypothesized that community members might be mobilized to clear the breeding sites of the vegetation that represents the primary black fly larvae attachment point. We evaluated the effect of such a community based "slash and clear...Continue Reading

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Citations

Apr 24, 2019·Tropical Medicine & International Health : TM & IH·Hugo C TurnerMaría-Gloria Basáñez
Jul 19, 2019·PLoS Neglected Tropical Diseases·Robert ColebundersMaria-Gloria Basáñez
Jan 25, 2020·Annual Review of Pathology·Tory P JohnsonAvindra Nath
Jul 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Natalie V S Vinkeles MelchersWilma A Stolk
Jul 28, 2020·Expert Review of Anti-infective Therapy·Philip MiltonMaría-Gloria Basáñez
Oct 30, 2020·Research and Reports in Tropical Medicine·Thomson LakwoDidier Bakajika
Jan 31, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jonathan I D HamleyMaria-Gloria Basáñez

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Methods Mentioned

BETA
MDA

Software Mentioned

SAS
ArcGIS

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