Community engagement and integrated health and polio immunisation campaigns in conflict-affected areas of Pakistan: a cluster randomised controlled trial

The Lancet Global Health
Muhammad Atif HabibZulfiqar A Bhutta

Abstract

Pakistan faces huge challenges in eradicating polio due to widespread poliovirus transmission and security challenges. Innovative interventions are urgently needed to strengthen community buy-in, to increase the coverage of oral polio vaccine (OPV) and other routine immunisations, and to enhance immunity through the introduction of inactivated polio vaccine (IPV) in combination with OPV. We aimed to evaluate the acceptability and effect on immunisation coverage of an integrated strategy for community engagement and maternal and child health immunisation campaigns in insecure and conflict-affected polio-endemic districts of Pakistan. We did a community-based three-arm cluster randomised trial in healthy children aged 1 month to 5 years that resided within the study sites in three districts of Pakistan at high risk of polio. Clusters were randomly assigned by a computer algorithm using restricted randomisation in blocks of 20 by an external statistician (1:1:1) to receive routine polio programme activities (control, arm A), additional interventions with community outreach and mobilisation using an enhanced communication package and provision of short-term preventive maternal and child health services and routine immunisation (hea...Continue Reading

References

Sep 1, 1991·Reviews of Infectious Diseases·P A PatriarcaT J John
May 26, 1999·International Journal of Epidemiology·R J Hayes, S Bennett
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Zulfiqar A Bhutta
Oct 16, 2014·The Journal of Infectious Diseases·James P AlexanderElias Durry
Jul 17, 2015·The Lancet Infectious Diseases·Julie R Garon, Walter A Orenstein
May 21, 2016·The Lancet Global Health·Nadia AkseerZulfiqar A Bhutta
Oct 13, 2016·Globalization and Health·Shoaib Fahad HussainRichard Sullivan
Jan 13, 2017·Journal of Public Health Policy·Muhammad Atif HabibZulfiqar Ahmed Bhutta

❮ Previous
Next ❯

Citations

May 8, 2018·The Cochrane Database of Systematic Reviews·Jessica KaufmanSophie Hill
Oct 19, 2017·Expert Review of Vaccines·James L GoodsonWalter A Orenstein
Dec 1, 2018·BMJ : British Medical Journal·Zulfiqar A BhuttaRenuka Jayatissa
Nov 2, 2019·Archives of Disease in Childhood·Zulfiqar Ahmed Bhutta
Aug 30, 2019·Human Vaccines & Immunotherapeutics·Mohamed F JallohDimitri Prybylski
Jul 28, 2017·Nature·Jaime Sepúlveda
Sep 19, 2019·International Health·Anthony Costello, Zainab Naimy
Jan 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amol A VermaFahad Razak
Feb 1, 2020·Global Bioethics = Problemi Di Bioetica·Bipin AdhikariPhaik Yeong Cheah
Jan 28, 2021·Lancet·Zulfiqar A BhuttaRobert E Black
Aug 11, 2020·Pregnancy Hypertension·Rahat N QureshiUNKNOWN CLIP Pakistan Working Group
Apr 27, 2021·Expert Review of Vaccines·Anushka AtaullahjanZulfiqar A Bhutta

❮ Previous
Next ❯

Methods Mentioned

BETA
IEC

Clinical Trials Mentioned

NCT01908114

Software Mentioned

Stata
Visual FoxPro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.