Community-onset and nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus in Spanish hospitals

Enfermedades infecciosas y microbiología clínica
Antonio B MillanGEIH/GEMARA/REIPI

Abstract

Community-onset infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are increasing. However, there is little information about community-onset bacteremia (CB) due to MRSA in Spain. The objectives of this study were to evaluate the prevalence, clinical and molecular epidemiology, clinical features, and prognosis of CB due to MRSA in comparison with nosocomial bacteremia (NB). Prospective multicenter cohort study; all new cases of bacteremia due to MRSA occurring during June 2003 in 59 Spanish hospitals were included. Episodes diagnosed during the first 48 hours of admission were considered CB, and otherwise, NB. Isolates were typed by pulsed field electrophoresis and multilocus sequence typing. Staphylococcal cassete chromosome mec types and Panton-Valentine leukocidin genes were studied by polymerase chain reaction. Sixty-four cases were included; 21 (33%) were classified as CB. In all CB cases, a relation was found with health care, or the isolate proved to be clonally related to nosocomial isolates. There were no significant differences between the groups in terms of demographic data, underlying conditions, prognosis, or characteristics of the isolates. Regarding the source of bacteremia, catheter-related ...Continue Reading

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Citations

Feb 5, 2013·Enfermedades infecciosas y microbiología clínica·Carlos Pigrau
Sep 26, 2012·Enfermedades infecciosas y microbiología clínica·Núria FreixasUNKNOWN VINCat Program

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