Comorbid depressive and anxiety symptoms and the risk of type 2 diabetes: Findings from the Lifelines Cohort Study

Journal of Affective Disorders
S DeschênesNorbert Schmitz

Abstract

Prior studies indicate that depression is a risk factor for type 2 diabetes (T2D), though there is considerable heterogeneity in reported estimates. Identifying homogeneous subgroups of depression strongly associated with T2D may be beneficial. This study examined associations between depression and anxiety comorbidity with the risk of T2D. 78,025 participants from the Lifelines Cohort Study (age range = 30-75 years) without diabetes at baseline were included in this study. The Mini-International Neuropsychiatric Interview assessed depressive and anxiety symptoms at baseline. Incident T2D was assessed by self-report or hemoglobin A1c levels during an approximately 3.8-year follow-up period. Risk of T2D was compared across four groups (no depressive or anxiety symptoms, depressive symptoms alone, anxiety symptoms alone, comorbid depressive/anxiety symptoms) using mixed effects logistic regression analyses adjusted for sociodemographic, lifestyle, and cardiometabolic characteristics. 1,096 participants developed diabetes. Compared to those without depressive or anxiety symptoms (n = 74,467), those with comorbid depressive and anxiety symptoms (n = 743) were more likely to develop T2D (n = 28, OR = 2.12, 95% CI = 1.22-3.68). Depre...Continue Reading

Citations

Jun 9, 2018·International Journal of Environmental Research and Public Health·Tania Guadalupe Gómez-PeraltaJosé Manuel Rodríguez-Pérez
Jul 9, 2020·Journal of Clinical Psychopharmacology·Hsin-Ya KuoChe-Sheng Chu
Jan 2, 2019·Journal of Affective Disorders·Weina LiuZhengtang Qi
Feb 21, 2021·Scandinavian Journal of Medicine & Science in Sports·Willem de BoerRuud Koning
Jul 3, 2021·International Journal of Environmental Research and Public Health·Marta Lopez-HerranzAna López-de-Andrés

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