Comorbid substance use and age at onset of schizophrenia

The British Journal of Psychiatry : the Journal of Mental Science
Thomas R E BarnesEileen M Joyce

Abstract

Substance use may be a risk factor for the onset of schizophrenia. To examine the association between substance use and age at onset in substance use and age at onset in a UK, inner-city sample of people with recent-onset schizophrenia. The study sample consisted of 152 people recruited to the West London First-Episode Schizophrenia Study. Self-reported data on drug and alcohol use, as well as information on age at onset of psychosis, were collected. Mental state, cognition (IQ, memory and executive function) and social function were also assessed. In total, 60% of the participants were smokers, 27% reported a history of problems with alcohol use, 35% reported current substance use (not including alcohol), and 68% reported lifetime substance use (cannabis and psychostimulants were most commonly used). Cannabis use and gender had independent effects on age at onset of psychosis, after adjusting for alcohol misuse and use of other drugs. The strong association between self-reported cannabis use and earlier onset of psychosis provides further evidence that schizophrenia may be precipitated by cannabis use and/or that the early onset of symptoms is a risk factor for cannabis use.

References

Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·M AsbergG Sedvall
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jan 1, 1976·Neuropsychologia·A L Thompson, J F Marsh
Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice
Jan 1, 1994·Schizophrenia Bulletin·P WeidenA Frances
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·P J DukeT R Barnes
Jun 1, 1994·Schizophrenia Research·C D MissarT E Goldberg
Apr 1, 1994·Archives of General Psychiatry·D H LinszenM E Lenior
Jan 1, 1996·Schizophrenia Bulletin·D V JesteJ P Lacro
Dec 1, 1996·Biological Psychiatry·M Hambrecht, H Häfner
Jan 1, 1997·The Journal of Nervous and Mental Disease·M F BrunetteR E Drake
May 8, 1998·Psychological Medicine·S B HuttonE M Joyce
Sep 30, 1998·Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism·R E Drake, M F Brunette
Apr 9, 1999·European Archives of Psychiatry and Clinical Neuroscience·D Caspari
Feb 2, 2000·Psychiatric Services : a Journal of the American Psychiatric Association·M OlfsonP J Weiden
Mar 18, 2000·Clinical Psychology Review·J J BlanchardA R Sherwood
Jul 6, 2000·The Australian and New Zealand Journal of Psychiatry·M Hambrecht, H Häfner
Oct 21, 2000·The British Journal of Psychiatry : the Journal of Mental Science·T R BarnesE M Joyce
Dec 4, 2001·The British Journal of Psychiatry : the Journal of Mental Science·P J DukeT R Barnes
May 16, 2002·The Journal of Nervous and Mental Disease·Ross M G Norman, Ashok K Malla
Jun 27, 2002·Schizophrenia Research·Jose de LeonFrancisco J Diaz
Sep 26, 2002·The British Journal of Psychiatry. Supplement·Eileen JoyceThomas Barnes
Jun 25, 2003·Drug and Alcohol Dependence·Louisa DegenhardtMichael Lynskey
Oct 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·T WeaverUNKNOWN Comorbidity of Substance Misuse and Mental Illness Collaborative study team
Nov 18, 2003·Acta Psychiatrica Scandinavica·S H MutsatsaT R E Barnes
Mar 3, 2004·The American Journal of Psychiatry·Natalie D VeenRené S Kahn
Mar 17, 2004·Social Psychiatry and Psychiatric Epidemiology·Sarah Van MastrigtDonald Addington
Mar 31, 2004·Addiction·Filip SmitPim Cuijpers
May 6, 2005·Journal of Psychopharmacology·David M SempleStephen M Lawrie
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Eileen M JoyceThomas R E Barnes

❮ Previous
Next ❯

Citations

Jun 19, 2008·Social Psychiatry and Psychiatric Epidemiology·Helen FisherSonia Johnson
Feb 3, 2009·Social Psychiatry and Psychiatric Epidemiology·Kathleen CrebbinDouglas Turkington
Mar 4, 2009·Social Psychiatry and Psychiatric Epidemiology·Köksal AlptekinYildiz Akvardar
Mar 16, 2012·Social Psychiatry and Psychiatric Epidemiology·Kudumallige K SureshBangalore N Gangadhar
Jun 19, 2013·Community Mental Health Journal·Wayne K DeruiterCarolyn S Dewa
Sep 9, 2011·Psychological Medicine·J H MeijerUNKNOWN Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Apr 15, 2010·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Sahoo SaddichhaChristoday Raja Jayant Khess
Mar 6, 2007·Schizophrenia Bulletin·Suzanne ArchieRobert B Zipursky
Jul 10, 2010·Substance Abuse Treatment, Prevention, and Policy·Chaturaka RodrigoSenaka Rajapakse
Sep 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Krzysztof KrystaJanusz K Rybakowski
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Kathleen CrebbinDouglas Turkington
Jul 1, 2009·Indian Journal of Psychological Medicine·Chaturaka Rodrigo, Senaka Rajapakse
Feb 4, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·T RütherH J Möller
May 20, 2014·Psychiatry Journal·Rudraprosad ChakrabortySuprakash Chaudhury
Mar 3, 2010·Annual Review of Clinical Psychology·Emma Barkus, Robin M Murray
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Aidan TurkingtonStephen J Cooper
May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Nov 13, 2007·The American Journal of Drug and Alcohol Abuse·Torrance StephensRonald L Braithwaite
Sep 10, 2013·Child and Adolescent Psychiatric Clinics of North America·Danielle Goerke, Sanjiv Kumra
Nov 5, 2013·Comprehensive Psychiatry·Prabhat ChandPratima Murthy
Dec 19, 2012·Psychiatry Research·Rachel A RabinTony P George
Oct 30, 2015·Journal of Dual Diagnosis·Belen ArranzLuis San
May 28, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·B G SchimmelmannM Lambert
Apr 19, 2011·Schizophrenia Research·Benno G SchimmelmannMartin Lambert
Mar 23, 2011·Schizophrenia Research·Rachel A RabinTony P George
Oct 30, 2015·Progress in Neurobiology·Yavuz AyhanMikhail V Pletnikov
Sep 10, 2010·Schizophrenia Research·José Manuel Rodríguez-SánchezBenedicto Crespo-Facorro
Aug 3, 2010·Schizophrenia Research·Marc De HertRuud van Winkel
Jul 6, 2010·Behavioural Brain Research·Yalchin AbdullaevThomas J Dishion
Aug 28, 2015·Nordic Journal of Psychiatry·Kristiina KivimiesJari Tiihonen
Jun 19, 2008·L'Encéphale·A Dervaux, X Laqueille
Aug 28, 2007·The Psychiatric Clinics of North America·Erick L MessiasWilliam W Eaton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.