Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease

British Journal of Haematology
Ferdows AtiqWiN Study Group

Abstract

Some comorbidities, such as hypertension, are associated with higher von Willebrand factor (VWF) levels in the general population. No studies have been conducted to assess this association in patients with von Willebrand disease (VWD). Therefore, we studied this association in patients with type 1 (n = 333) and type 2 (n = 203) VWD from the 'WiN" study. VWF antigen (VWF:Ag) was higher in type 1 VWD patients with hypertension [difference: 0·23 iu/ml, 95% confidence interval (CI): 0·11-0·35], diabetes mellitus (0·11 iu/ml, 95% CI: -0·02 to 0·23), cancer (0·14 iu/ml, 95% CI: 0·03-0·25) and thyroid dysfunction (0·14 iu/ml, 95% CI: 0·03-0·26) than in patients without these comorbidities (all corrected for age, sex and blood group). Similar results were observed for VWF collagen binding capacity (VWF:CB), VWF activity as measured by the VWF monoclonal antibody assay (VWF:Ab) and factor VIII (FVIII) coagulant activity (FVIII:C). In type 1 VWD, age was associated with higher VWF:Ag (0·03 iu/ml; 95% CI: 0·01-0·04), VWF:CB (0·02 iu/ml; 95% CI: 0·00-0·04), VWF:Ab (0·04 iu/ml; 95% CI: 0·02-0·06) and FVIII:C (0·03 iu/ml; 95% CI: 0·01-0·06) per decade increase. After adjustment for relevant comorbidities, these associations were no longer si...Continue Reading

Associated Clinical Trials

May 11, 2018·Frank W.G. Leebeek, MD, PhD

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Citations

Nov 15, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Ferdows AtiqUNKNOWN WiN study group
May 1, 2019·American Journal of Hematology·Ferdows AtiqUNKNOWN WiN study group
Apr 28, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Caroline S B VeenMarieke J H A Kruip
May 3, 2020·International Journal of Laboratory Hematology·Charlotte RobertsonHenry Watson
Jul 7, 2020·Thrombosis and Haemostasis·Craig D Seaman, Margaret V Ragni
Oct 1, 2020·Journal of Thrombosis and Haemostasis : JTH·Eugenia BiguzziFlora Peyvandi
Nov 23, 2020·Thrombosis Research·Eugenia BiguzziAstrid van Hylckama Vlieg
Dec 22, 2020·Journal of Thrombosis and Haemostasis : JTH·Dearbhla DohertyJames S O'Donnell
Aug 14, 2020·The Science of the Total Environment·Qingqing LiangZhiwei Sun
Jun 11, 2021·Blood·Catherine P M Hayward
Dec 8, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Beverly A SchaeferPeter Kouides
Dec 11, 2021·Hematology·Mouhamed Yazan Abou-Ismail, Nathan T Connell

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Methods Mentioned

BETA
blood drawing
antibody assay
antibody

Software Mentioned

SPSS Statistics

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