Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO).

Frontiers in Cardiovascular Medicine
Francesca PolverinoItaliCO study group

Abstract

Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID-19. Whether hypertension medications may increase the risk for death in older COVID 19 inpatients at the highest risk for the disease is currently unknown. Methods: Data from 5,625 COVID-19 inpatients were manually extracted from medical charts from 61 hospitals across Italy. From the initial 5,625 patients, 3,179 were included in the study as they were either discharged or deceased at the time of the data analysis. Primary outcome was inpatient death or recovery. Mixed effects logistic regression models were adjusted for sex, age, and number of comorbidities, with a random effect for site. Results: A large proportion of participating inpatients were ≥65 years old (58%), male (68%), non-smokers (93%) with comorbidities (66%). Each additional comorbidity increased the risk of death by 35% [adjOR = 1.35 (1.2, 1.5) p < 0.001]. Use of ACE inhibitors, ARBs, beta-blockers or Ca-antagonists was not associated with significantly increased risk of ...Continue Reading

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Citations

Sep 20, 2020·Journal of Clinical Medicine·Elisabetta CocconcelliElisabetta Balestro
Jan 29, 2021·The American Journal of Cardiology·Haiyan YangYadong Wang
Feb 5, 2021·Frontiers in Medicine·Francesca Polverino, Farrah Kheradmand
Aug 19, 2021·Internal and Emergency Medicine·Alessandra BanderaUNKNOWN COVID-19 Network Working Group
Aug 25, 2021·BMC Pulmonary Medicine·M TomchaneyF Polverino
Sep 3, 2021·PloS One·Grace M VaheyUNKNOWN Colorado Investigation Team

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Software Mentioned

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