Comorbidities in patients with persistent or chronic immune thrombocytopenia.

International Journal of Hematology
Cheryl EngerAndrew T McAfee

Abstract

There is a paucity of epidemiological data on the risk of comorbidities in adults with persistent or chronic immune thrombocytopenia (ITP). In this study, we compared the rates of cataracts, diabetes, renal failure, vascular events, lymphoma, and leukemia among patients with and without persistent or chronic ITP. Using administrative data, adult patients with medical claims for ITP from January, 2000 through September, 2006 were identified. An age- and gender-matched comparison cohort without evidence of ITP was randomly selected. The incidence rate ratio (IRR) of each comorbidity among ITP patients relative to the comparison group was estimated using Poisson regression, adjusting for baseline covariates. A total of 3,131 patients with persistent or chronic ITP were identified, and 9,392 were selected for the comparison cohort. The adjusted IRRs were as follows: diabetes 1.73 (95% CI 1.36-2.20), renal failure 2.05 (95% CI 1.67-2.51), any vascular event 1.70 (95% CI 1.41-2.05), lymphoma 5.91 (95% CI 2.61-13.37), leukemia 19.83 (95% CI 5.84-67.34), and mortality 4.21 (95% CI 3.06-5.79). There was no increased risk for cataract or myocardial infarction in the ITP cohort. Patients with persistent or chronic ITP are at increased ris...Continue Reading

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Citations

Jun 27, 2012·Journal of Thrombosis and Thrombolysis·Rie TabataYoshio Kita
Nov 9, 2015·American Journal of Hematology·Francesco Rodeghiero
Jan 29, 2013·The British Journal of Surgery·C C ChangT L Chen
Apr 17, 2016·International Journal of Hematology·Wendy J LangebergScott Stryker
May 21, 2016·European Journal of Haematology·Indraraj Umesh DoobareeDrew Provan
Jan 31, 2017·La Revue de médecine interne·G MoulisL Sailler
Aug 15, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ján Mihalov, Gabriela Timárová
Jan 4, 2018·Blood·Shruti ChaturvediKeith R McCrae
Oct 27, 2018·International Journal of Laboratory Hematology·Hui Yin LimPrahlad Ho
Apr 2, 2019·Journal of Thrombosis and Haemostasis : JTH·Kasper AdelborgChristian Fynbo Christiansen
Apr 6, 2012·Expert Review of Hematology·Henrik FrederiksenMette Nørgaard
Jul 12, 2019·American Journal of Hematology·Dennis Lund HansenHenrik Frederiksen
Oct 3, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lishou PanHan-Ting Zhang
Jul 22, 2020·Annals of Hematology·Fathima HaseefaMehrnoosh Hashemzadeh
Apr 7, 2021·British Journal of Haematology·Dawn SwanJecko Thachil
Nov 21, 2020·Blood Reviews·Wobke E M van DijkRolf T Urbanus

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