Comorbidity and functional status are independent in older cancer patients

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
M ExtermannL Balducci

Abstract

Comorbidity is a frequent and often therapeutically limiting problem in older cancer patients. However, to date, there is no standard measure of the comorbidity burden available for these patients. We tested the performance of two comorbidity scales and their relationship with functional status. The Cumulative Illness Rating Scale-Geriatric (CIRS-G) was compared with the Charlson scale in 203 patients who received a comprehensive geriatric assessment (CGA) in our Senior Adult Oncology Program (SAOP). Study end points were variability, reliability, correlation with Eastern Cooperative Oncology Group (ECOG) performance status (PS), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL). The relative weight of comorbidity versus tumor stage in the correlations with functional status was assessed. Median age was 75 years (range, 63 to 91). Sixty-four percent of patients scored 0 on the Charlson scale versus 6% on the CIRS-G. The correlation between the Charlson and CIRS-G was fair (p = 0.25 to 0.39). CIRS-G grade 3/4 had a fair correlation with ADL (p = 0.27). Otherwise, there was low or no correlation between comorbidity and functional status across the measures. Tumor stage was not correlated with fu...Continue Reading

Citations

Dec 4, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Gary H LymanLodovico Balducci
Dec 4, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Stuart M Lichtman
Aug 10, 2004·Journal of Cancer Research and Clinical Oncology·G NagelD Katenkamp
Nov 6, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ritesh MistryUNKNOWN UPBEAT Collaborative Group
Dec 22, 2004·Current Oncology Reports·Marisa F Siebel, Hyman B Muss
Mar 22, 2005·The British Journal of Surgery·V E P P LemmensJ W W Coebergh
Jul 5, 2005·Journal of Palliative Medicine·Joan HarroldDavid Casarett
Oct 6, 2005·Cancer·Arti HurriaAlice B Kornblith
Jan 6, 2006·The Cancer Journal·Martine Extermann
Feb 24, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ulrich WeddingKlaus Höffken
Aug 31, 2007·Drugs & Aging·Lara Maria PasettoSilvio Monfardini
Oct 13, 2007·Der Internist·A H Leischker, G F Kolb
Oct 22, 2008·The Journal of Urology·Nicole L SimoneMark S Litwin
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea L ChevilleAlice B Kornblith
Apr 11, 2009·Current Treatment Options in Oncology·Mary LeungDaniel R Budman
May 5, 2009·Current Opinion in Oncology·Lodovico Balducci
Sep 25, 2008·Journal of the American Geriatrics Society·Fabio SalviPaolo Dessì-Fulgheri
Aug 4, 2009·Cancer Chemotherapy and Pharmacology·Noelle K LoConteKyle D Holen
Jul 30, 2009·Qualitative Health Research·Nic HughesDavid Clark
Jun 17, 2010·Annals of Surgical Oncology·Charles T TuggleJulie Ann Sosa
Feb 6, 2010·Expert Review of Anticancer Therapy·Sandro BarniFausto Petrelli
Dec 17, 2009·Hematology·Michael Hallek
Sep 24, 2010·Journal of the National Cancer Institute·Dejana BraithwaiteBette J Caan
Jan 1, 2010·Acta Medica (Hradec Králové)·Lukás Smolej
Jul 27, 2011·American Journal of Physical Medicine & Rehabilitation·Andrea L ChevilleJeffrey R Basford
Nov 19, 2011·Journal of the American Geriatrics Society·Lynn PoynterMichael Vassallo
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre SoubeyranMuriel Rainfray
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William G Wierda
Jul 5, 2012·Women's Health·Trevor JollyHyman B Muss
Oct 3, 2013·Expert Review of Hematology·Mohamed L Sorror, Frederick R Appelbaum
Sep 13, 2014·Leukemia & Lymphoma·Nimish ShahSimon Rule

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