Comorbidity and primary treatment for localized prostate cancer: data from CaPSURE

The Journal of Urology
Paige L MarrPeter R Carroll

Abstract

The optimal approach for treating localized prostate cancer remains controversial, leading to a multifactorial decision making process. We characterized the extent to which the presence and number of comorbidities affects treatment for localized prostate cancer. Data were abstracted from a longitudinal observational database of men with prostate cancer. A total of 5,149 men diagnosed with localized prostate cancer between 1995 and 2001 were included in this analysis if they had been treated with RP, external beam radiation, brachytherapy, hormonal therapy or surveillance. Comorbidity was assessed through a patient reported checklist of conditions. Multinomial logistic regression was used to determine the OR of the likelihood of receiving each type of therapy. The number of comorbidities and specific comorbidities in patients receiving RP were compared with comorbidities in patients receiving other treatment. The adjusted OR showed a dose response between the number of comorbidities and an increasing probability of any nonRP treatment. In addition, heart disease, stroke or another urinary condition were found to be associated with treatment. Patient comorbidities affect decision making regarding treatment for localized prostate ...Continue Reading

References

May 15, 1991·Cancer·C L BennettR M Elashoff
Sep 9, 2000·Archives of Otolaryngology--head & Neck Surgery·J F Piccirillo
Dec 26, 2001·Journal of the National Cancer Institute·L C HarlanR A Stephenson
Jan 5, 2002·CA: a Cancer Journal for Clinicians·J W Yates
Feb 6, 2002·Seminars in Urologic Oncology·Timothy J Wilt
Jan 7, 2004·Urology·E David Crawford
Jan 7, 2004·Urology·E David Crawford
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll

❮ Previous
Next ❯

Citations

Sep 22, 2011·Journal of General Internal Medicine·Karim ChamieMark S Litwin
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Seth K BechisMatthew R Cooperberg
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E David CrawfordAnthony V D'Amico
Feb 22, 2011·The Journal of Urology·Karim ChamieMark S Litwin
Sep 18, 2009·The Journal of Urology·Geoffrey A SonnMark S Litwin
Apr 24, 2015·Scandinavian Journal of Urology·Christina G JespersenMichael Borre
Jan 6, 2015·International Journal of Clinical Oncology·Zuzana ObertováPeter Gilling
Apr 2, 2016·Therapeutic Advances in Urology·Piotr ZarebaJehonathan H Pinthus
Dec 19, 2012·The Journal of Urology·Geoffrey A SonnMark S Litwin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.