Comorbidity and sex-related differences in mortality in oxygen-dependent chronic obstructive pulmonary disease.

PloS One
Magnus EkströmKerstin E Ström

Abstract

It is not known why survival differs between men and women in oxygen-dependent chronic obstructive pulmonary disease (COPD). The present study evaluates differences in comorbidity between men and women, and tests the hypothesis that comorbidity contributes to sex-related differences in mortality in oxygen-dependent COPD. National prospective study of patients aged 50 years or older, starting long-term oxygen therapy (LTOT) for COPD in Sweden between 1992 and 2008. Comorbidities were obtained from the Swedish Hospital Discharge Register. Sex-related differences in comorbidity were estimated using logistic regression, adjusting for age, smoking status and year of inclusion. The effect of comorbidity on overall mortality and the interaction between comorbidity and sex were evaluated using Cox regression, adjusting for age, sex, Pa(O2) breathing air, FEV(1), smoking history and year of inclusion. In total, 8,712 patients (55% women) were included and 6,729 patients died during the study period. No patient was lost to follow-up. Compared with women, men had significantly more arrhythmia, cancer, ischemic heart disease and renal failure, and less hypertension, mental disorders, osteoporosis and rheumatoid arthritis (P<0.05 for all od...Continue Reading

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Citations

Jan 31, 2013·Current Opinion in Pulmonary Medicine·Firas KamilMarilyn G Foreman
Aug 21, 2013·Expert Review of Respiratory Medicine·Elisabeth A P M RommeEmiel F M Wouters
Dec 29, 2013·Current Opinion in Pulmonary Medicine·Douglas Mapel
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Jul 17, 2019·Journal of Comorbidity·Irini Gergianaki, Ioanna Tsiligianni
Sep 3, 2016·American Journal of Respiratory and Critical Care Medicine·Sara RoversiAlvar Agustí
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Apr 2, 2013·American Journal of Respiratory and Critical Care Medicine·Enrico M CliniLeonardo M Fabbri
Jun 2, 2018·Panminerva Medica·Antonello NicoliniFulvio Braido
Mar 1, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Christophe Gut-GobertChantal Raherison
Sep 19, 2019·Kardiologiia·Z R AisanovE N Kalmanova
Mar 23, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sara C ButteryLowie E G W Vanfleteren
Aug 7, 2021·Clinics in Chest Medicine·Christine Jenkins

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