Abstract
It is not known why survival differs between men and women in oxygen-dependent chronic obstructive pulmonary disease (COPD). The present study evaluates differences in comorbidity between men and women, and tests the hypothesis that comorbidity contributes to sex-related differences in mortality in oxygen-dependent COPD. National prospective study of patients aged 50 years or older, starting long-term oxygen therapy (LTOT) for COPD in Sweden between 1992 and 2008. Comorbidities were obtained from the Swedish Hospital Discharge Register. Sex-related differences in comorbidity were estimated using logistic regression, adjusting for age, smoking status and year of inclusion. The effect of comorbidity on overall mortality and the interaction between comorbidity and sex were evaluated using Cox regression, adjusting for age, sex, Pa(O2) breathing air, FEV(1), smoking history and year of inclusion. In total, 8,712 patients (55% women) were included and 6,729 patients died during the study period. No patient was lost to follow-up. Compared with women, men had significantly more arrhythmia, cancer, ischemic heart disease and renal failure, and less hypertension, mental disorders, osteoporosis and rheumatoid arthritis (P<0.05 for all od...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Sep 1, 1980·Annals of Internal Medicine
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·K MiyamotoY Kawakami
Mar 1, 1996·Chest·E ChailleuxJ M Polu
Mar 11, 1998·The European Respiratory Journal·R Antonelli IncalziR Pistelli
Nov 27, 2001·Internal Medicine Journal·A J CrockettJ H Alpers
May 15, 2002·Chest·Pedro AlmagroJavier Garau
Aug 27, 2005·European Journal of Epidemiology·Tomas AnderssonAnders Ahlbom
Oct 21, 2005·Chest·Juan P de TorresBartolome R Celli
Oct 21, 2005·Chest·Joan B SorianoAnna L Hansell
Mar 15, 2006·European Journal of Heart Failure·Frans H RuttenArno W Hoes
Apr 6, 2006·The European Respiratory Journal·S MartiJ Ferrer
Jun 17, 2006·American Journal of Respiratory and Critical Care Medicine·Maria-Christina L MachadoWilliam M Vollmer
Sep 30, 2006·Health and Quality of Life Outcomes·Juan P de TorresBartolome R Celli
Nov 16, 2006·European Journal of Epidemiology·Suellen M CurkendallEarl Goehring
Mar 3, 2007·Respiratory Medicine·Karl A FranklinKerstin Ström
Jun 19, 2007·Chest·Mark T DransfieldWilliam C Bailey
Jun 27, 2008·The European Respiratory Journal·D M ManninoF Holguin
Dec 3, 2008·The European Respiratory Journal·J P de TorresB R Celli
Sep 15, 2009·Chest·Magnus EkströmKerstin E Ström
Nov 3, 2009·Respiratory Medicine·P AlmagroUNKNOWN Grupo Epoc De La Sociedad Española De Medicina Interna
Apr 13, 2010·Chest·Akane HarunaMichiaki Mishima
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Bartolome CelliUNKNOWN Investigators of the TORCH Study
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Nicola A HananiaUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study investigators
Dec 21, 2010·Lung·Timothy L LashHenrik Toft Sørensen
Jan 11, 2011·American Journal of Respiratory and Critical Care Medicine·Magnus P EkströmKerstin E Ström
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Citations
Jan 31, 2013·Current Opinion in Pulmonary Medicine·Firas KamilMarilyn G Foreman
Aug 21, 2013·Expert Review of Respiratory Medicine·Elisabeth A P M RommeEmiel F M Wouters
Dec 29, 2013·Current Opinion in Pulmonary Medicine·Douglas Mapel
Oct 30, 2013·European Journal of Clinical Investigation·Sara RoversiLeonardo M Fabbri
Jan 18, 2018·PeerJ·Chu-Hsu LinChia-Hung Lin
Jul 17, 2019·Journal of Comorbidity·Irini Gergianaki, Ioanna Tsiligianni
Sep 3, 2016·American Journal of Respiratory and Critical Care Medicine·Sara RoversiAlvar Agustí
Apr 16, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robert J HancoxMalcolm R Sears
Jul 2, 2020·Vaccines·Silvia CocchioVincenzo Baldo
Jul 12, 2016·COPD·Nurdan KokturkPaul W Jones
Apr 2, 2013·American Journal of Respiratory and Critical Care Medicine·Enrico M CliniLeonardo M Fabbri
Jun 2, 2018·Panminerva Medica·Antonello NicoliniFulvio Braido
Nov 27, 2018·BMC Family Practice·Elzbieta KaszubaAnders Halling
Apr 3, 2015·The Clinical Respiratory Journal·ShuYi GuHuiPing Li
Mar 1, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Christophe Gut-GobertChantal Raherison
Sep 19, 2019·Kardiologiia·Z R AisanovE N Kalmanova
Mar 23, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sara C ButteryLowie E G W Vanfleteren
Aug 7, 2021·Clinics in Chest Medicine·Christine Jenkins