Comorbidity is associated with pain-related activity limitations in multiple sclerosis

Multiple Sclerosis and Related Disorders
Kirsten FiestCIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS)

Abstract

Comorbidities are common in multiple sclerosis (MS). The high prevalence of pain in MS is well-established but the influence of comorbidities on pain, specifically, pain-related interference in activity is not. To examine the relationship between comorbidity and pain in MS. We recruited 949 consecutive patients with definite MS from four Canadian centres. Participants completed the Health Utilities Index (HUI-Mark III) and a validated comorbidity questionnaire at 3 visits over 2 years. The HUI's pain scale was dichotomized into two groups: those with/without pain that disrupts normal activities. We used logistic regression to assess the association of pain with each comorbidity individually at baseline and over time. The incidence of disruptive pain over two years was 31.1 per 100 persons. Fibromyalgia, rheumatoid arthritis, irritable bowel syndrome, migraine, chronic lung disease, depression, anxiety, hypertension, and hypercholesterolemia were associated with disruptive pain (p<0.006). Individual-level effects on the presence of worsening pain were seen for chronic obstructive pulmonary disease (odds ratio [OR]: 1.50 95% CI: 1.08-2.09), anxiety (OR: 1.49 95% CI: 1.07-2.08), and autoimmune thyroid disease (OR: 1.40 95% CI: 1.0...Continue Reading

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Citations

May 3, 2016·International Journal of MS Care·Kirsten M FiestUNKNOWN CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS)
Dec 23, 2017·Health and Quality of Life Outcomes·Kirsten M FiestRuth Ann Marrie
Jan 19, 2018·JMIR Research Protocols·Ruth Ann MarrieCharles N Bernstein
Sep 3, 2020·Journal of Neurology·Lara Marie Pangan LoIngrid van der Mei
Mar 25, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R ScherderE Scherder
Oct 6, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Tiffany J BraleyAnna L Kratz
May 26, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A ThormannM Magyari
Mar 16, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Kathleen M ZackowskiAnthony Feinstein
Mar 18, 2021·Perspectives in Psychiatric Care·Şükrü ÖzenÜlkü Polat

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