Comorbidity is independently associated with poor outcome in extremity soft tissue sarcoma

Clinics in Orthopedic Surgery
Seungcheol KangI Han

Abstract

Comorbidity has not been examined as an independent prognostic factor in soft tissue sarcoma (STS). We examined the prognostic impact of comorbidity on oncologic outcome in STS with an adjustment for possible confounding factors. A retrospective review was performed on 349 patients who had undergone surgery for high-grade localized STS of extremity at our institute. Conditions known to alter the risk of mortality, as defined in the Charlson comorbidity index, were classified as comorbidities and 43 patients (12%) had at least one comorbidity at the time of surgery. The association of comorbidity and oncologic outcomes of local recurrence-free survival (LRFS) and disease-specific survival (DSS) were tested with adjustment for confounding factors. Comorbidity was associated with old age, high tumor grade, and large tumor size. The presence of comorbidity was independently associated with poor LRFS and DSS, even after adjusting for confounding factors including age and treatment variables. Our data suggest that the presence of comorbidity is an independent prognostic factor for extremity STS.

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Citations

Jul 28, 2017·Acta Radiologica·Karen De Amorim BernsteinMiriam A Bredella
Sep 11, 2019·American Journal of Clinical Oncology·Daniela GretoLorenzo Livi
May 20, 2016·Medicine·Yan YangHai-Ping Mao
Nov 28, 2018·Journal of Gynecologic Oncology·Violante Di DonatoPierluigi Benedetti Panici
Jan 25, 2020·Sarcoma·Rosa Álvarez ÁlvarezClaudia María Valverde
Jan 3, 2019·Clinical Orthopaedics and Related Research·Zachary MayoBenjamin J Miller
Sep 18, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Takeshi MoriiShoichi Ichimura

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