Comorbidity prevalence and treatment outcome in children and adolescents with ADHD

European Child & Adolescent Psychiatry
Laura RealeLombardy ADHD Group

Abstract

Although ADHD comorbidity has been widely studied, some issues remain unsolved. This multicenter observational study aims to examine comorbid psychiatric disorders in a clinical sample of newly diagnosed, treatment naïve children and adolescents with and without ADHD and, to compare treatment efficacy based on the type of comorbidity. We performed an analysis of the medical records of patients identified from the Regional ADHD Registry database, enrolled in 18 ADHD centers in the 2011-2016 period. 1919 of 2861 subjects evaluated (67%) met the diagnostic criteria for ADHD: 650 (34%) had only ADHD, while 1269 (66%) had at least one comorbid psychiatric disorder (learning disorders, 56%; sleep disorders, 23%; oppositional defiant disorder, 20%; anxiety disorders, 12%). Patients with ADHD of combined type and with severe impairment (CGI-S ≥5) were more likely to present comorbidity. 382 of 724 (53%) followed up patients improved after 1 year of treatment. ADHD with comorbidity showed greater improvement when treated with combined interventions or methylphenidate alone. Specifically, combined treatment showed significant superiority for ADHD with learning disorders (ES 0.66) and ODD (ES 0.98), lower for ADHD with sleep or anxiety di...Continue Reading

References

Jun 1, 1978·Journal of Abnormal Child Psychology·C H GoyetteR F Ulrich
Nov 1, 1991·Journal of Child Psychology and Psychiatry, and Allied Disciplines·C Caron, M Rutter
Apr 1, 1983·Journal of Child Psychology and Psychiatry, and Allied Disciplines·C GillbergP Rasmussen
Aug 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·P S JensenD P Cantwell
Oct 23, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·S V FaraoneT Spencer
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Jul 16, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·B Kadesjö, C Gillberg
Dec 5, 2000·Journal of Abnormal Child Psychology·J S MarchW E Pelham
Feb 24, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·P S JensenB Vitiello
Feb 24, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·J H NewcornB Vitiello
Jan 31, 2002·Annual Review of Medicine·Timothy E WilensThomas J Spencer
Aug 3, 2004·Pediatrics·Pietro PaneiAlessandro Zuddas
Jul 19, 2005·Lancet·Joseph Biederman, Stephen V Faraone
Sep 24, 2005·Archives of Disease in Childhood·J BiedermanS V Faraone
Jan 31, 2007·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Thomas J SpencerEric Mick
May 17, 2007·Journal of Abnormal Child Psychology·José J BauermeisterGlorisa Canino
Feb 8, 2008·European Child & Adolescent Psychiatry·Tobias BanaschewskiVeit Roessner
Apr 30, 2008·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·William E Pelham, Gregory A Fabiano
Jul 5, 2008·Child and Adolescent Psychiatry and Mental Health·Josephine EliaWade Berrettini
Dec 26, 2008·Journal of Child and Adolescent Psychopharmacology·W Burleson Daviss
Jan 24, 2009·European Child & Adolescent Psychiatry·Alessandra FrigerioMassimo Molteni
May 4, 2011·European Journal of Clinical Pharmacology·Anna DidoniUNKNOWN Lombardy ADHD Registry Group
May 9, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonio ClavennaMaurizio Bonati
Jun 1, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Kouichi YoshimasuSlavica K Katusic
Sep 12, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Anita ThaparKate Langley
Nov 13, 2012·Journal of Learning Disabilities·George J DuPaulSeth D Laracy
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
Oct 17, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Erik PetterssonPaul Lichtenstein
Oct 24, 2013·Journal of Attention Disorders·Yvonne ZengleinChristine M Freitag
Nov 20, 2013·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Steven W EvansNora Bunford
Dec 18, 2013·BMJ : British Medical Journal·Maurizio Bonati, Laura Reale
Feb 5, 2014·Expert Review of Neurotherapeutics·Roumen Kirov, Serge Brand
Jun 20, 2014·Attention Deficit and Hyperactivity Disorders·Christina Mohr Jensen, Hans-Christoph Steinhausen
Aug 13, 2014·Asia-Pacific Journal of Public Health·Subin ParkHee-Jeong Yoo
Oct 12, 2014·Clinical Pediatrics·Tanjala T GipsonMary L Leppert

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Citations

Oct 7, 2017·Expert Opinion on Drug Safety·Antonio Clavenna, Maurizio Bonati
Nov 22, 2017·European Child & Adolescent Psychiatry·Paul Ramchandani
Mar 1, 2018·Nordic Journal of Psychiatry·Berit Hjelde HansenHanne Kristensen
Mar 5, 2019·European Child & Adolescent Psychiatry·Nir MadjarGal Shoval
Jul 5, 2019·European Journal of Clinical Pharmacology·Daniele PiovaniMaurizio Bonati
Nov 26, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Yael DvirUNKNOWN ELGAN Study Investigators
Sep 4, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Beatriz RedondoRaimundo Jiménez
Aug 2, 2018·Journal of Attention Disorders·Gloria T HanSusan Shur-Fen Gau
Apr 19, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Rubén MolinaRaimundo Jiménez
May 19, 2020·Human Brain Mapping·Xiang-Zhen KongClyde Francks
Jul 4, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Grant L IversonRichard J McNally
Sep 30, 2017·International Journal of Psychiatry in Clinical Practice·Pavel Golubchik, Abraham Weizman
Jun 8, 2018·European Child & Adolescent Psychiatry·Maurizio BonatiUNKNOWN Lombardy ADHD Group
Jul 1, 2020·Soa--chʻŏngsonyŏn Chŏngsin Ŭihak = Journal of Child & Adolescent Psychiatry·Ram HwangboGeon Ho Bahn
Aug 8, 2020·Child and Adolescent Psychiatry and Mental Health·Marie ElwinJan-Olov Larsson
Feb 26, 2019·Frontiers in Human Neuroscience·Yuyang LuoXiaobo Li
Oct 1, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gianluca TrifiròGiovanni Corrao
Apr 4, 2020·European Child & Adolescent Psychiatry·Joana Roigé-CastellvíJosefa Canals
Oct 19, 2017·Child and Adolescent Psychiatry and Mental Health·Katri MaasaloEeva T Aronen
Jul 10, 2018·Child and Adolescent Psychiatry and Mental Health·Pernille Darling RasmussenNiels Bilenberg
Feb 12, 2021·Social Psychiatry and Psychiatric Epidemiology·Joe BatheltDuncan E Astle
Nov 5, 2020·Expert Opinion on Emerging Drugs·Ann C ChildressMargaret D Weiss
Feb 23, 2021·Nordic Journal of Psychiatry·Akın TahıllıoğluEyüp Sabri Ercan
Mar 8, 2021·European Child & Adolescent Psychiatry·Kristin Romvig OvergaardPål Zeiner
Mar 23, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Merel C PostemaClyde Francks

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