Compact fiber-based multi-photon endoscope working at 1700 nm

Biomedical Optics Express
Farhad AkhoundiKhanh Kieu

Abstract

We present the design, implementation and performance analysis of a compact multi-photon endoscope based on a piezo electric scanning tube. A miniature objective lens with a long working distance and a high numerical aperture (≈ 0.5) is designed to provide a diffraction limited spot size. Furthermore, a 1700 nm wavelength femtosecond fiber laser is used as an excitation source to overcome the scattering of biological tissues and reduce water absorption. Therefore, the novel optical system along with the unique wavelength allows us to increase the imaging depth. We demonstrate that the endoscope is capable of performing third and second harmonic generation (THG/SHG) and three-photon excitation fluorescence (3PEF) imaging over a large field of view (> 400 μm) with high lateral resolution (2.2 μm). The compact and lightweight probe design makes it suitable for minimally-invasive in-vivo imaging as a potential alternative to surgical biopsies.

References

Apr 6, 1990·Science·W DenkW W Webb
Apr 22, 2006·Optics Letters·Mon Thiri MyaingXingde Li
Aug 4, 2009·Optics Letters·Gangjun LiuZhongping Chen
May 15, 1996·Optics Letters·D L Dickensheets, G S Kino
Aug 31, 2010·Journal of Biomedical Optics·Rodrigo Aviles-EspinosaPablo Loza-Alvarez
Jan 25, 2011·Biomedical Optics Express·Youbo ZhaoRobert J Gordon
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·David R RiveraChris Xu
Apr 20, 2012·Optics Letters·David R RiveraChris Xu
May 15, 2013·Biomedical Optics Express·David M HulandChris Xu
Nov 2, 2013·Optics Letters·Wendy-Julie MadoreCaroline Boudoux
Jan 15, 2014·Nature Photonics·C Xu, F W Wise
Jun 28, 2014·Journal of Biomedical Optics·Dukho DoDae-Gab Gweon
Dec 18, 2015·Scientific Reports·Guillaume DucourthialFrédéric Louradour
Jan 29, 2016·Biomedical Optics Express·Soroush MehravarKhanh Kieu
May 28, 2016·Biomedical Optics Express·N V KuzminM L Groot

❮ Previous
Next ❯

Citations

Aug 15, 2020·Inflammatory Bowel Diseases·Mariane Le FurPeter Caravan
Jul 8, 2020·Optics Letters·Guan-Yu ZhuoMing-Che Chan
Jul 25, 2020·Light, Science & Applications·Jiawen LiRobert A McLaughlin
Sep 20, 2020·Nature Reviews. Nephrology·Suman RanjitMoshe Levi
Jun 6, 2020·Biomedical Optics Express·Farhad Akhoundi, N Peyghambarian
Jul 21, 2021·Light, Science & Applications·Jiawen LiRobert A McLaughlin
Nov 16, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vytautas KučikasMarc A M J van Zandvoort

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.