PMID: 15376770Sep 21, 2004Paper

Compact intra- and extracorporeal oxygenator developments

Perfusion
Giorgio CattaneoHelmut Reul

Abstract

For patients with acute lung failure, mechanical ventilation entails the risk of lung tissue damage due to high oxygen pressure and concentration. Membrane oxygenation for one to two weeks can rest the lungs due to decreased ventilation parameters, representing a potential bridge to recovery, but implies the substantial risks of blood damage, plasma leakage and infection, which often have fatal results for patients. At the Helmholtz Institute in Aachen, two types of membrane oxygenators, which aim to overcome previous limits, are under development. Both present compact designs, reduced surface and priming volumes and easier handling. HEXMO is a miniaturized extracorporeal membrane oxygenator. The integration of a small rotary blood pump into the centre of the oxygenator reduces the amount of tubing and connectors in the system. Blood is convectively warmed by the pump motor housing, thus, the use of a heat-exchanger can be avoided. This compact design reduces surface and priming volume and allows better handling, especially in critical situations. A second development is the intravascular oxygenator HIMOX, which is inserted directly into the vena cava. Priming volume and blood contact surface are reduced, as well as infection r...Continue Reading

References

Nov 1, 1994·Artificial Organs·S A ConradR N Schaap
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon

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Citations

Mar 24, 2007·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Eisuke Tatsumi
Mar 25, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Giorgio F M CattaneoUlrich Steinseifer
Apr 11, 2008·Critical Care Medicine·Dinna CruzClaudio Ronco
May 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ju ZhaoCun Long
Nov 26, 2010·Artificial Organs·Roland GraefeUlrich Steinseifer
Jan 31, 2009·Current Opinion in Critical Care·Antonio PesentiNicolò Patroniti
Sep 25, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jutta ArensUlrich Steinseifer
Nov 26, 2010·Artificial Organs·Ralf BorchardtUlrich Steinseifer
Apr 23, 2014·Artificial Organs·R Garrett JeffriesWilliam J Federspiel
Feb 15, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ruedger KoppDietrich Henzler
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Heide J EashWilliam J Federspiel
Aug 25, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yuan YuanPing Liu
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jutta ArensRolf Rossaint
Mar 7, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jutta ArensRolf Rossaint
May 17, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ralf BorchardtUlrich Steinseifer
Aug 27, 2021·ACS Biomaterials Science & Engineering·Meili ZhangJohn F Fraser
Feb 18, 2010·Lancet·Thomas BeinSteffen Weber-Carstens

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