Compact, power-efficient architectures using microvalves and microsensors, for intrathecal, insulin, and other drug delivery systems

Advanced Drug Delivery Reviews
Tao LiYogesh B Gianchandani

Abstract

This paper describes a valve-regulated architecture, for intrathecal, insulin and other drug delivery systems, that offers high performance and volume efficiency through the use of micromachined components. Multi-drug protocols can be accommodated by using a valve manifold to modulate and mix drug flows from individual reservoirs. A piezoelectrically-actuated silicon microvalve with embedded pressure sensors is used to regulate dosing by throttling flow from a mechanically-pressurized reservoir. A preliminary prototype system is demonstrated with two reservoirs, pressure sensors, and a control circuit board within a 130cm(3) metal casing. Different control modes of the programmable system have been evaluated to mimic clinical applications. Bolus and continuous flow deliveries have been demonstrated. A wide range of delivery rates can be achieved by adjusting the parameters of the manifold valves or reservoir springs. The capability to compensate for changes in delivery pressure has been experimentally verified. The pressure profiles can also be used to detect catheter occlusions and disconnects. The benefits of this architecture compared with alternative options are reviewed.

References

Mar 15, 1992·Analytical Chemistry·G Reach, G S Wilson
Aug 1, 1991·Anesthesia and Analgesia·D W Coombs, N Fine
Oct 25, 1980·British Medical Journal·J S Crawford
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Sep 1, 1996·Journal of Neurosurgery·M Winkelmüller, W Winkelmüller
Sep 18, 1997·Journal of Pain and Symptom Management·E S Krames, K Olson
Mar 10, 2001·Journal of Pain and Symptom Management·S Mercadante, R K Portenoy
Sep 29, 2001·Journal of Pain and Symptom Management·N G RainovW Burkert
Oct 26, 2001·Current Pain and Headache Reports·T S GrabowP S Staats
Mar 23, 2002·Stereotactic and Functional Neurosurgery·E I UhleH Bertalanffy
Jul 10, 2003·Journal of Pain and Symptom Management·Laurie L AckermanRichard W Rosenquist
Aug 9, 2003·Journal of Pain and Symptom Management·Sebastiano MercadanteEdoardo Arcuri
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Mar 5, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Timothy DeerKim Burchiel
Sep 24, 2004·Anesthesia and Analgesia·Stephan StrebelChristoph H Kindler
Mar 3, 2005·Biosensors & Bioelectronics·John C PickupNabihah Sachedina
Apr 28, 2005·Biosensors & Bioelectronics·George S Wilson, Raeann Gifford
Apr 28, 2005·Biosensors & Bioelectronics·Jeffrey D Newman, Anthony P F Turner
Apr 28, 2005·Biosensors & Bioelectronics·Peter T Kissinger
Jun 7, 2005·Neurotoxicology·Tsukasa SakuradaShinobu Sakurada
Jan 18, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·R Hovorka
Nov 17, 2006·Der Schmerz·R LikarM C Spendel
Feb 21, 2007·Pain Practice : the Official Journal of World Institute of Pain·Serdar Erdine, José De Andrés
Dec 25, 2007·Chemical Reviews·Joseph Wang
Jan 30, 2008·Anesthesia and Analgesia·Mark S WallaceUNKNOWN Ziconotide 98-022 Study Group
Mar 28, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn R WebsterMichael MineHart
Aug 22, 2008·Diabetes Technology & Therapeutics·Irl B HirschBruce A Buckingham
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Nov 26, 2009·Biomedical Microdevices·Allan Thomas EvansYogesh B Gianchandani
Nov 26, 2009·Biomedical Microdevices·Allan T EvansYogesh B Gianchandani

❮ Previous
Next ❯

Citations

Jul 3, 2013·Current Opinion in Anaesthesiology·Jose De AndresGustavo Fabregat-Cid
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Feb 24, 2015·Advanced Healthcare Materials·Angelica CoboEllis Meng
Jul 8, 2020·Micromachines·Farzad ForouzandehDavid A Borkholder
Nov 3, 2016·Journal of Diabetes Science and Technology·Marzia CesconEyal Dassau
Jul 3, 2021·Pharmaceuticals·Farzad ForouzandehDavid A Borkholder

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.