Company Profile: HistoRx: tissue-based diagnostic solutions for personalized medicine

Personalized Medicine
Marisa Dolled-FilhartMark Gustavson

Abstract

The mission of HistoRx (CT, USA) is to develop and commercialize clinically actionable immunohistochemical (IHC) biomarker assays with the distinctive characteristic of being as quantitative, objective and standardized as the measurement of glucose in blood. In clinical laboratory practice, serum glucose measurement is expected to give the same result regardless of the laboratory or operator performing the test, and the same should be true for tissue-based IHC tests in anatomical pathology. By offering such improvements to standard IHC analysis using reproducible AQUA® assays, patients will benefit from standardized results for determination of appropriate targeted therapeutic drug treatment.

References

Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Dec 22, 2005·Journal of the National Cancer Institute·Anthony McCabeDavid L Rimm
Feb 23, 2007·The New England Journal of Medicine·Zhong ZhengGerold Bepler
Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Allen M Gown
Mar 26, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mark D GustavsonJason Christiansen
Jan 1, 2007·Archives of Pathology & Laboratory Medicine·Antonio C WolffUNKNOWN American Society of Clinical Oncology/College of American Pathologists
Sep 3, 2009·Archives of Pathology & Laboratory Medicine·Mark D GustavsonJason Christiansen
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bonnie E Gould RothbergDavid L Rimm
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Craig ReynoldsGerold Bepler
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Jul 31, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antonio GualbertoAdrian V Lee
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allison W WelshDavid L Rimm

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Citations

Nov 1, 2012·Personalized Medicine·Marisa P Dolled-FilhartJimmy Cheng-Ho Lin

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Methods Mentioned

BETA
fluorescence imaging
biopsies

Clinical Trials Mentioned

NCT00215930

Software Mentioned

AQUA
Genoptix
OncotypeDX
HistoRx
AQUA Automated Quantitative Analysis

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