Comparability and repeatability of methods for estimating the dietary intake of the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP).

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Nicole C DezielPaul T Strickland

Abstract

Inconsistent risk estimates for dietary heterocyclic amine (HCA) exposure and cancers may be due to differences in exposure assessment methods and the associated measurement error. We evaluated repeatability and comparability of intake estimates of the HCA 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) among two food frequency questionnaire (FFQ) collections, three diary collections, and three measurements of urinary PhIP and its metabolites in 36 non-smokers in Baltimore, Maryland, during 2004-2005. Collections spanned ∼9 months. Method repeatability was characterised with intraclass correlation coefficients (ICCs). Comparability among methods was assessed with Spearman correlation coefficients. Within-subject variability in PhIP intake was comparably high across all methods (ICCs of 0.20, 0.30, and 0.15 for FFQ, diary, and creatinine-adjusted urinary PhIP, respectively). Mean diary-based PhIP intake and mean urinary PhIP concentration were strongly correlated when restricting the analysis to participants with at least one non-zero diary-based estimate of PhIP intake (n = 15, r = 0.75, p = 0.001), but not in the full study population (n = 36, r = 0.18, p = 0.28). Mean PhIP intake from the FFQ was not associated with tha...Continue Reading

References

May 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Larsen
Oct 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H P ThiébaudJ S Felton
Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektA Aromaa
May 12, 1997·Mutation Research·R Sinha, N Rothman
Feb 17, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R ReistadJ Alexander
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·C MagagnottiL Airoldi
Nov 4, 2000·Journal of the National Cancer Institute·C P SalmonJ S Felton
Apr 20, 2001·Nutrition Reviews·T Norat, E Riboli
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N KazerouniN Rothman
Nov 20, 2001·Chemical Research in Toxicology·L S DeBruinP D Josephy
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Skog
Sep 28, 2002·Mutation Research·Rashmi Sinha
Mar 5, 2003·American Journal of Epidemiology·L M ButlerR S Sandler
Aug 15, 2003·Obesity Research·Pamela S HainesBarry M Popkin
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marie CantwellRashmi Sinha
Apr 10, 2004·Cancer Science·Takashi SugimuraMinako Nagao
Jun 30, 2005·Molecular Nutrition & Food Research·Rashmi SinhaJoanne Holden
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristin E AndersonRashmi Sinha
Dec 17, 2005·Cancer Research·Amanda J CrossRashmi Sinha
Oct 13, 2006·Journal of Agricultural and Food Chemistry·Rosa BusquetsKerstin Skog
Nov 30, 2006·Psychology, Health & Medicine·UNKNOWN The National Institute Of Mental Health Multisite HIV Prevention Trial Group
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Aesun ShinWei Zheng
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Donghui LiManal M Hassan
Jul 31, 2007·Journal of the American Dietetic Association·Garrett A KeatingJune M Chan
Oct 24, 2007·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M S AlaejosA M Afonso
Dec 6, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C NaccariD Trombetta
Jul 11, 2009·Chemical Research in Toxicology·Erin E BessetteRobert J Turesky
Jul 16, 2009·European Journal of Clinical Nutrition·F B ScagliusiA H Lancha
Feb 26, 2010·Epidemiologic Perspectives & Innovations : EP+I·Laurence S FreedmanNancy Potischman
May 8, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kana WuEunyoung Cho
Mar 25, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nicole C DezielTimothy J Buckley

❮ Previous
Next ❯

Citations

Jan 19, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert J TureskyLoïc Le Marchand
May 16, 2015·Critical Reviews in Food Science and Nutrition·Daniel DemeyerMichèle Ulens

❮ Previous
Next ❯

Methods Mentioned

BETA
urine collection
PhIP
urine collections

Software Mentioned

ChemStation
Stata
CHARRED
Nutrition Data System for Research©

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.