Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses

Vaccine
Gerwin D RodenburgElisabeth A M Sanders

Abstract

In this cohort study we compared IgG antibody levels between infants immunized with 7-valent CRM197-conjugated pneumococcal vaccine (PCV-7) at 2, 4 and 11 months and at 2, 3, 4 and 11 months of age, as measured by double adsorption ELISA. Pre- and post-booster levels following the 2+1- and 3+1-dose schedule were comparable for 5 out of 7 serotypes except for serotypes 6B and 19F. The proportion of children reaching post-booster antibody thresholds were comparable except for 6B (>or=1.0 microg/ml and >or=5.0 microg/ml) and 19F (>or=5.0 microg/ml). Surveillance studies are warranted for vaccine impact on 6B and 19F disease cases after reduced-dose PCV-7 schedules.

References

Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Catherine M WernetteMoon H Nahm
Feb 11, 2005·The Pediatric Infectious Disease Journal·Helena KäyhtyLennart Nilsson
Jul 5, 2005·The Journal of Infectious Diseases·David GoldblattElizabeth Miller
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugene V MillarMathuram Santosham
Oct 11, 2008·The Pediatric Infectious Disease Journal·Philippe De WalsMonique Douville-Fradet
Feb 10, 2009·Vaccine·Paolo DurandoUNKNOWN Collaborative Group for Pneumococcal Vaccination in Liguria
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Elske J M van GilsElisabeth A M Sanders

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Citations

Dec 18, 2013·The Pediatric Infectious Disease Journal·Maria Deloria KnollKatherine L O'Brien
Mar 26, 2011·Expert Review of Vaccines·Bernard Fritzell, Mark A Fletcher
May 25, 2011·Expert Review of Vaccines·Geraldine Blanchard-Rohner, Andrew J Pollard
Jul 15, 2015·The Pediatric Infectious Disease Journal·Jolice P van den BergRuurd M van Elburg
Feb 24, 2019·Archives of Disease in Childhood·Petra ZimmermannNigel Curtis

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