PMID: 7524236Oct 1, 1994Paper

Comparability of the Tandem-R and IMx assays for the measurement of serum prostate-specific antigen

Urology
S J JacobsenJ E Oesterling

Abstract

To assess the comparability of the Tandem-R and IMx serum prostate-specific antigen (PSA) assays across levels of the ratio of free-to-total serum PSA found in a community-based population of healthy men. Banked serum samples from the baseline component of the Olmsted County Study of Urinary Symptoms and Health Status Among Men were thawed and analyzed using the Tandem-R and IMx PSA assays. Serum levels also were determined for the free, noncomplexed form of PSA, PSA complexed to alpha-1 antichymotrypsin, and total PSA with a research-based immunofluorometric assay. The results of the Tandem-R and IMx assays were strongly correlated at all levels of the ratio of free-to-total serum PSA. The Spearman correlation coefficients ranged from 0.87 to 0.98 (all p < 0.001). The relationship between the Tandem-R and IMx assays, however, differed at low levels of free-to-total serum PSA compared with high levels. In the lowest 10th percentile of the ratio of free-to-total serum PSA (0.04 to 0.18), the IMx assay read lower than the Tandem-R (slope +/- standard error = 0.92 +/- 0.04, intercept +/- standard error = 0.21 +/- 0.14); whereas in the upper 10th percentile of free-to-total ratio (0.46 to 0.65) the IMx assay yielded values higher t...Continue Reading

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Citations

Jul 1, 1995·The Prostate·M K BrawerM H Wener
Jan 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·C Becker, H Lilja
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T M PisanskyJ E Oesterling
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T M PisanskyH Zincke
Apr 1, 1996·Urology·M B TchetgenJ E Oesterling
May 1, 1997·The Urologic Clinics of North America·P A AbrahamssonJ E Oesterling
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Jan 4, 2012·Mayo Clinic Proceedings·Steven J JacobsenMichael M Lieber

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