Nov 5, 2003

Comparable outcomes of radiation therapy without high-dose methotrexate for patients with primary central nervous system lymphoma

Japanese Journal of Clinical Oncology
Hitoshi IshikawaTakashi Nakano


The previous trials of radiotherapy conducted for primary central nervous system lymphoma (PCNSL) have not been successful. Therefore, we have investigated the clinical outcomes and the role of radiation therapy in the treatment of PCNSL. Thirty-three consecutive patients with PCNSL treated with cranial radiotherapy (30-40 Gy whole brain plus 10-20 Gy boost) without administration of high-dose methotrexate were retrospectively analyzed. Nine patients received whole spinal irradiation (WSI) as an additional therapy. The median age of patients was 58 years (range: 28-78 years), and 70% showed a poor performance status (PS). The median survival time (MST) was 13 months, and the 5-year overall survival rate was 35%. The initial response and the number of tumors were significant prognostic factors, and WSI tended toward significance in a multivariate analysis. Four of five patients, who received prophylactic WSI, were 4-year survivors without a tumor relapse and none of them had tumor involvement in the vertebral canal. One patient developed radiation-induced brain necrosis, however, WSI did not seem to affect the late complications. We consider it important to reduce severe acute and late complications in patients qualified for rec...Continue Reading

  • References
  • Citations8


  • We're still populating references for this paper, please check back later.
  • References
  • Citations8

Mentioned in this Paper

Prosthesis Failure
Administration Procedure
Therapeutic Radiology Procedure
Prophylactic Treatment
Spinal Canal
Central Nervous System Neoplasms, Primary

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Related Papers

Journal of Cancer Research and Clinical Oncology
Yuta ShibamotoNaofumi Hayabuchi
Current Treatment Options in Neurology
Manmeet S Ahluwalia, David M Peereboom
Current Oncology Reports
Igor T Gavrilovic, Lauren E Abrey
© 2020 Meta ULC. All rights reserved