Comparable Survival of En Bloc versus Standard Donor Kidney Transplants in Children

The Journal of Pediatrics
Erica WinnickiLavjay Butani

Abstract

To determine whether renal transplantation survival is similar in children receiving pediatric en bloc kidneys compared with those receiving standard deceased donor kidneys. We compared time to allograft failure and estimated glomerular filtration rate (eGFR) in pediatric recipients of en bloc and standard criteria deceased donor renal transplants using Organ Procurement and Transplantation Network data for 2000-2013. Cox regression analysis was used to compare time to allograft failure, and the Student t test was used to compare eGFR. A total of 6882 recipients met the study inclusion criteria; 1.8% received an en bloc transplant. The adjusted hazard for allograft failure was similar for recipients of en bloc kidneys compared with standard criteria kidneys (hazard ratio, 1.15; 95% CI, 0.83-1.59; P = .41). The median wait time for transplantation was significantly shorter for recipients of en bloc kidneys (157 days vs 208 days; P = .03). Moreover, eGFR was superior for recipients of en bloc kidneys up to 5 years post-transplantation. Transplantation of en bloc pediatric kidneys should be considered a viable option for pediatric recipients and may afford unique benefits by reducing wait times and promoting preservation of graft ...Continue Reading

References

Mar 1, 1985·The Journal of Pediatrics·G J Schwartz, B Gauthier
Jan 1, 1974·Archives of Surgery·O S AndersenF K Merkel
Aug 17, 2002·The Journal of Pediatrics·R S ParekhF K Port
Oct 28, 2003·Transplantation·Ana I Sánchez-FructuosoAlberto Barrientos
Apr 19, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J W Groothoff
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Charles R Nolan
Dec 31, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido F LaubeThomas J Neuhaus
May 17, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stuart L GoldsteinJames W Varni
Jul 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L PapeG Offner
Aug 15, 2006·Transplantation·Kalathil K SureshkumarBarbara J Carpenter
Feb 12, 2008·Transplantation Proceedings·G M Abouna
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Jun 6, 2009·Pediatric Transplantation·Keith K LauLavjay Butani
Jun 16, 2010·Transplantation·Suverta BhayanaKanae Ishihara
Mar 1, 2012·Pediatric Transplantation·Mickael AfanettiEtienne Berard
Nov 23, 2012·Pediatric Transplantation·Lavjay ButaniRichard V Perez
Feb 5, 2013·Transplantation Proceedings·H W JungS W Yang
Apr 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rebecca J Johnson, Bradley A Warady
Sep 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D G MalufS Feng
Jan 30, 2015·JAMA Surgery·Abbas RanaRainer W G Gruessner

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Citations

Apr 12, 2017·Pediatric Transplantation·H C YaffeL K Kayler
Aug 15, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S M NazarianM H Levine
Feb 15, 2019·Current Opinion in Pediatrics·Vaka Kristin Sigurjonsdottir, Paul Charles Grimm
May 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chia-Shi WangJulien Hogan
Sep 22, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Samir DamjiNizam Mamode
Jan 15, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jayanthi ChandarGeorge Burke
Feb 6, 2020·Transplantation·Sarah J KizilbashBlanche M Chavers
Oct 18, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Jinna YaoHenry C C Pleass
Oct 10, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Metin CetinerAnja K Büscher

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