Comparative ACE2 variation and primate COVID-19 risk.

BioRxiv : the Preprint Server for Biology
Amanda D MelinJames P Higham

Abstract

The emergence of the novel coronavirus SARS-CoV-2, which in humans is highly infectious and leads to the potentially fatal disease COVID-19, has caused hundreds of thousands of deaths and huge global disruption. The viral infection may also represent an existential threat to our closest living relatives, the nonhuman primates, many of which are endangered and often reduced to small populations. The virus engages the host cell receptor, angiotensin-converting enzyme-2 (ACE2), through the receptor binding domain (RBD) on the spike protein. The contact surface of ACE2 displays amino acid residues that are critical for virus recognition, and variations at these critical residues are likely to modulate infection susceptibility across species. While infection studies are emerging and have shown that some primates, such as rhesus macaques and vervet monkeys, develop COVID-19-like symptoms when exposed to the virus, the susceptibility of many other nonhuman primates is unknown. Here, we show that all apes, including chimpanzees, bonobos, gorillas, and orangutans, and all African and Asian monkeys (catarrhines), exhibit the same set of twelve key amino acid residues as human ACE2. Monkeys in the Americas, and some tarsiers, lemurs and l...Continue Reading

Citations

Aug 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Joana DamasHarris A Lewin
Aug 21, 2020·Mucosal Immunology·M D JohansenP M Hansbro
Sep 17, 2020·Human Vaccines & Immunotherapeutics·Idris Nasir AbdullahiAbdurrahman El-Fulaty Ahmad
Sep 25, 2020·Emerging Microbes & Infections·Khalid MunirXin Zhao
Mar 16, 2021·International Journal of Primatology·Paul A Garber
Dec 7, 2021·Frontiers in Cellular and Infection Microbiology·Brandon J BeddingfieldChad J Roy

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

RAxML
Geneious
R package ips
SSIPe
MrBayes
MAFFT
Rosetta
PAML
codeml
TimeTree

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

BioRxiv : the Preprint Server for Biology
Amanda D MelinJames P Higham
Communications Biology
Amanda D MelinJames P Higham
BioRxiv : the Preprint Server for Biology
Amanda D MelinJames P Higham
BioRxiv : the Preprint Server for Biology
Amanda D MelinJ. P. Higham
American Journal of Primatology
Amanda D MelinJames P Higham
© 2022 Meta ULC. All rights reserved