PMID: 9188277Jun 1, 1997Paper

Comparative action spectrum for ultraviolet light killing of mouse melanocytes from different genetic coat color backgrounds

Photochemistry and Photobiology
H Z HillR E Boissy

Abstract

The photobiology of mouse melanocyte lines with different pigment genotypes was studied by measuring colony-forming ability after irradiation. The cell lines were wild-type black (melan-a) and the mutants brown (melan-b) and albino (melan-c). Four lamps emitting various UV wavelengths were used. These were germicidal (UVC, 200-280 nm), 82.3% output at 254 nm, TL01 (UVB, 280-320 nm), 64.2% at 310-311 nm, FS20, broadband with peak output at 312 nm and Alisun-S (UVA, 320-400 nm), broadband with peak output at 350-354 nm. Appropriate filtration reduced the contaminating UVC to nonlethal levels for the longer waverange lamps. Wild-type melan-a was resistant to UVC and UVA compared to the other two cell lines, but the differences were small. The melan-c cell line was more resistant to UVB and markedly more resistant to FS20 than the pigmented lines. With the exception of FS20 responses, melan-b was more sensitive than melan-a to killing by the various UV lamps. There were more pyrimidine dimers (cyclobutane dimers and 6-4 photoproducts) produced in melan-a than in melan-c cells by UVC, UVB and FS20 lamps. Unlike melan-c, melan-a and melan-b showed a strong free radical signal of melanin character with a detectable contribution of phe...Continue Reading

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Citations

Jul 7, 1999·Journal of Photochemistry and Photobiology. B, Biology·G ThumannU Schraermeyer
Dec 17, 2009·Photochemistry and Photobiology·David Mitchell, Becky Brooks
Feb 5, 2009·Pigment Cell & Melanoma Research·Thomas J HornyakFaith M Strickland
Aug 20, 2003·The Journal of Investigative Dermatology·Egil Kvam, Jostein Dahle
Apr 17, 2009·Experimental Dermatology·Przemyslaw M Plonka
Aug 23, 2005·Journal of Photochemistry and Photobiology. B, Biology·Aoen BoligeKen Goto
Jun 19, 2002·Journal of Theoretical Biology·Leiv ØyehaugStig W Omholt
Sep 21, 2016·Photochemistry and Photobiology·Stuart G Jarrett, John A D'Orazio
Feb 14, 2017·Pigment Cell & Melanoma Research·Stuart Gordon JarrettJohn August D'Orazio
Dec 18, 2001·Environmental and Molecular Mutagenesis·J Kaur, H Z Hill
Oct 12, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Stéphane MouretThierry Douki
Jun 22, 2012·Experimental Dermatology·Agnieszka Wolnicka-GlubiszPrzemyslaw M Plonka
Mar 22, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Benjamin RiouxMercedes Quintana

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