PMID: 8942338Oct 1, 1996Paper

Comparative actions of propofol and thiopentone on cell membranes of isolated guineapig ventricular myocytes

British Journal of Anaesthesia
F SakaiK Amaha

Abstract

We have examined the effects of propofol and thiopentone on membrane potentials and currents of isolated guineapig ventricular myocytes using the whole-cell patch-clamp technique. After current clamping, propofol at concentrations greater than 0.5 mumol litre-1 shortened the plateau and action potential duration (APD) (P < 0.05). Thiopentone 10 mumol litre-1 prolonged APD (P < 0.05), whereas concentrations of 50 mumol litre-1 or higher decreased plateau height (P < 0.05) and resting membrane potential (RMP) (P < 0.05) with abbreviation of the prolonged APD. With voltage clamping, propofol 1 mumol litre-1 decreased the L-type Ca2+ current (ICa,L) to 88.4% of control (P < 0.01) without affecting the delayed rectifier K+ current (IK) and propofol 10 mumol litre-1 decreased ICa,L and IK to 75.0% (P < 0.01) and 78.4% (P < 0.01), respectively, with no effect on the inward rectifier K+ current (IK1). Thiopentone 10 mumol litre-1 decreased ICa,L to 88.5% (P < 0.01) and IK to 78.3% (P < 0.05), while thiopentone 100 mumol litre-1 depressed ICa,L to 82.8% (P < 0.01), IK to 27.0% (P < 0.01) and IK1 to 67.3% (P < 0.05). These results indicated that propofol, at concentrations greater than those that are clinically relevant, shortened APD ma...Continue Reading

Citations

Oct 11, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rie Kato, Pierre Foëx
Feb 13, 2001·British Journal of Pharmacology·J van KlarenboschJ J de Lange
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·D A Saint, Y Tang
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Katja E OdeningGideon Koren
May 8, 2010·European Journal of Pharmacology·Angélica López-IzquierdoJosé A Sánchez-Chapula
Oct 12, 2005·Journal of Pharmacological Sciences·Hideki SuzukiJunko Kimura
Jun 18, 2010·Journal of Cardiovascular Pharmacology·Albert DunninkMarc A Vos

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