PMID: 8606798Nov 1, 1995Paper

Comparative actions of synthetic omega-grammotoxin SIA and synthetic omega-Aga-IVA on neuronal calcium entry and evoked release of neurotransmitters in vitro and in vivo

Neuropharmacology
R A KeithB A Donzanti

Abstract

The effects of synthetic omega-grammotoxin SIA (omega-GsTxSIA) and synthetic omega-Aga-IVA were tested in in vitro and in vivo neurochemical assays that are reflective of voltage-sensitive calcium channel function. Synthetic omega-GsTx SIA inhibited K(+)-evoked rat and chick synaptosomal 45Ca2+ flux, K(+)-evoked release of [3H]D-aspartate and [3H]norepinephrine from rat hippocampal brain slices and K(+)-evoked release of [3H]norepinephrine from chick cortical brain slices with potency values that were comparable to those found previously with omega-GsTx SIA purified from the venom of the tarantula spider Grammostola spatulata. These results indicate that trace contaminants do not account for the pharmacology of purified omega-GsTx SIA. omega-GsTx SIA caused a complete inhibition of rat synaptosomal 45Ca2+ flux and hippocampal slice [3H]D-aspartate release, whereas omega-Aga-IVA caused a maximal inhibition of approx 75%. omega-GsTx SIA and omega-Aga-IVA caused an identical partial inhibition of K(+)-evoked increases of intracellular calcium in cortical neurons in primary culture. The addition of nitrendipine to either omega-GsTx SIA or omega-Aga-IVA resulted in an additive and virtually complete inhibition of the cortical neuron...Continue Reading

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Citations

Apr 7, 2004·Toxicon : Official Journal of the International Society on Toxinology·Pierre Escoubas, Lachlan Rash
Aug 7, 2002·Journal of Molecular Biology·Koh TakeuchiIchio Shimada
Dec 2, 2000·Neurochemistry International·D D SavageA M Allan
Nov 19, 2002·Neuroscience Letters·Frank RichterHans-Georg Schaible
Nov 20, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·A K Singh, Y Jiang
Apr 10, 2007·Toxicon : Official Journal of the International Society on Toxinology·Herlinda ClementLourival D Possani
May 18, 2004·Brain Research. Brain Research Reviews·Wudayagiri RajendraKandiah Jeyaseelan
Jun 11, 2004·European Journal of Pharmacology·Renê de O BeleboniWagner F Dos Santos

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