Comparative activity of azithromycin and doxycycline against Brucella spp. infection in mice

The Journal of Antimicrobial Chemotherapy
S DomingoC Gamazo

Abstract

The activities of a short therapeutic regimen with azithromycin and the classic treatment doxycycline with streptomycin were compared and evaluated in mice infected with Brucella melitensis. In a chronic model, starting therapy 31 days after challenge, azithromycin (10 days, 50 mg/kg/day) significantly reduced the infection (2.9 logs, day 48 post-infection). The effectiveness of doxycycline (21 days, 50 mg/kg/12 hourly) was greater than azithromycin (4.1 logs of reduction, day 48 post-infection), and when doxycycline was administered for a period of 45 days, all the animals were bacteriologically cured from day 78. The combination with streptomycin (14 days, 10 mg/kg/day) did not improve the effect of any of the regimens. In an acute model infection, treatments with doxycycline or doxycycline-streptomycin, for a period of 3 days, starting 1 day after lethal challenge, were able to protect all the mice. In contrast, only 50% of the mice treated with azithromycin survived the challenge. In conclusion, although a short oral treatment with azithromycin was able to reduce the infection significantly, it was not able to cure the animals as effectively as the classic regimen with doxycycline administered for a longer period of time.

Citations

Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SoleraUNKNOWN Grupo de Estudio de Castilla la Mancha de Enfermedades Infecciosas Group
Jul 15, 2009·Clinical Microbiology Reviews·Gary P Wormser, Ira Schwartz
Dec 22, 2009·International Journal of Antimicrobial Agents·Helen S AtkinsAndrew J H Simpson
Jul 26, 2005·International Journal of Antimicrobial Agents·Georgios PappasEpameinondas Tsianos
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Georgios PappasEpameinondas Tsianos
Mar 26, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Mehmet Faruk GeyikCelal Ayaz

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