Comparative activity of carbapenem testing (the COMPACT study) in Turkey.

BMC Infectious Diseases
Hakan LeblebiciogluTurkish COMPACT Study Group

Abstract

Recent evidence indicates that Gram-negative bacterial pathogens, the most common of which are Pseudomonas spp., Enterobacteriaceae, and Acinetobacter baumannii, are frequent causes of hospital-acquired infections. This study aims to evaluate the in vitro activity of doripenem and comparator carbapenem antibiotics against Gram-negative clinical isolates collected from COMParative Activity of Carbapenem Testing (COMPACT) study centres in Turkey. Ten centres in Turkey were invited to submit Pseudomonas aeruginosa, Enterobacteriaceae, and other Gram-negative isolates from intensive care unit (ICU)/non-ICU patients with complicated intra-abdominal infections, bloodstream infections, or nosocomial pneumonia, including ventilator-associated pneumonia, between May and October 2008. Susceptibility was determined by each centre using E-test. A central laboratory performed species confirmation as well as limited susceptibility and quality-control testing. Five hundred and ninety six isolates were collected. MIC90 values for doripenem, meropenem, and imipenem, respectively, were 32, ≥ 64, and ≥ 64 mg/L against Pseudomonas spp.; 0.12, 0.12, and 0.5 mg/L against Enterobacteriaceae; and ≥ 64 mg/L for each against other Gram-negative isolates...Continue Reading

References

Sep 25, 2007·Diagnostic Microbiology and Infectious Disease·Volkan KortenUNKNOWN Turkish MYSTIC Study Group
Oct 10, 2008·The Journal of Antimicrobial Chemotherapy·David M LivermoreUNKNOWN BSAC Working Parties on Resistance Surveillance
Dec 17, 2008·Diagnostic Microbiology and Infectious Disease·Philip J Turner
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Patrice NordmannUNKNOWN COMPACT study group

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Citations

Aug 24, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Frank HansenUlrik Stenz Justesen
May 14, 2016·Journal of Applied Microbiology·M DouraghiA Abdollahi
Jul 4, 2013·The Annals of Pharmacotherapy·Lama HsaikyRaymond Cha

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Software Mentioned

COMPACT

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