Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
A PurohitN Frossard

Abstract

Cetirizine and desloratadine are antihistamines active in the treatment of symptoms associated with seasonal allergic rhinitis and chronic urticaria. To compare the antihistamine activity of desloratadine, the active metabolite of loratadine, with that of cetirizine in the skin wheal-and-flare responses during 24 hours. This was a double-blind, randomized, placebo-controlled, single oral dose, crossover study. Skin reaction to histamine (100 mg/mL), administered by prick tests, was measured by the wheal and flare surface areas for 24 hours (before treatment and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 hours). Eighteen healthy volunteers (mean age, 33.9 years; 13 women) participated in this study. The areas under the curves of the wheal-and-flare responses as a function of time (primary efficacy variables) were compared using analysis of variance. A highly significant overall treatment effect (P < .001) was detected for wheal and flare inhibition, with the activity of cetirizine and desloratadine significantly superior to that of placebo (P < .001). In addition, the activity of cetirizine was significantly superior to that of desloratadine (P < .001). With desloratadine, only 3 of the 18 subjects achieved a wheal inhibition of a...Continue Reading

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Citations

May 10, 2005·Immunology and Allergy Clinics of North America·Sachin Baxi, Chitra Dinakar
Feb 28, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·James H DayMaureen P Briscoe
Aug 20, 2009·Pediatric Dermatology·Devang R Doshi, Miles M Weinberger
Jun 1, 2013·Indian Journal of Dermatology·Martin K Church, Diana S Church
Dec 7, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·William E Berger
Nov 22, 2005·Dermatologic Therapy·Michael O'Donoghue, Michael D Tharp
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P Devillier, J Bousquet
Mar 19, 2016·International Forum of Allergy & Rhinology·Qiong Du, Yingchun Zhou
Dec 23, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Andrew Crowe, Cameron Wright
Aug 16, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Julie BrevardMartin M Bednar
Oct 2, 2007·American Journal of Clinical Dermatology·Lawrence DuBuske
Sep 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Phichayut PhinyoMati Chuamanochan
Mar 1, 2011·The World Allergy Organization Journal·Diana S Church, Martin K Church

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