PMID: 3758551Aug 1, 1986Paper

Comparative acute toxicity of four nickel compounds to F344 rat lung

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J M BensonA H Rebar

Abstract

Nickel subsulfide (Ni3S2), nickel chloride (NiCl2), nickel sulfate (NiSO4), and nickel oxide (NiO) are compounds of widely differing solubility encountered in the nickel-refining and electroplating industries. Inhalation is a common route of exposure and toxicity to the respiratory tract is possible. The purpose of this study was to evaluate the biochemical, cytological, and morphological changes in lung following administration of these compounds by intratracheal instillation. F344/Crl rats were administered a single dose of nickel compound containing 0.0, 0.01, 0.10, or 1.0 mumol Ni by intratracheal instillation. Rats were sacrificed at 1 or 7 days after compound administration, with half the animals in each exposure group taken for determination of nickel lung burden and the remaining half used for evaluation of biochemical, cytological, and histological changes. In the latter group, the right lung was lavaged and the fluid obtained was analyzed for indicators of pulmonary inflammation: lactate dehydrogenase (LDH), beta-glucuronidase (BG), total protein (TP), glutathione reductase (GR), glutathione peroxidase (GP), and sialic acid (SA). Total and differential cell counts on cells recovered in lavage fluid were also determine...Continue Reading

Citations

Oct 11, 2011·Environmental Geochemistry and Health·Mallory DrysdaleRon T Watkins
Apr 15, 2004·Toxicology and Applied Pharmacology·Konstantin SalnikowMorton Lippmann
Jun 17, 2015·Analytical and Bioanalytical Chemistry·Miriam KüpperYngvar Thomassen
Jan 1, 1988·Toxicologic Pathology·J A KnightF W Sunderman
Jan 1, 1994·Food Additives and Contaminants·M Waseem, J L Kaw
Jun 12, 2009·Critical Reviews in Toxicology·Julie E GoodmanSagar Thakali
Jan 1, 1988·Journal of Toxicology and Environmental Health·M W ConnerM O Amdur
Jan 1, 1989·Critical Reviews in Toxicology·T P CooganM Costa
Dec 17, 2010·Critical Reviews in Toxicology·Julie E GoodmanAdriana R Oller
Jan 21, 2011·Journal of Environmental Monitoring : JEM·Caboche JulienLaurent Y Alleman

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