Comparative airway response to high- versus low-molecular weight agents in occupational asthma

The European Respiratory Journal
M-H DufourL P Boulet

Abstract

Airway responses to occupational agents in sensitised workers may vary clinically and physiologically. The patterns of change in airway responsiveness, type of response and fall in expiratory flows following laboratory exposure to high- or low-molecular weight agents (HMW and LMW agents, respectively) were compared in sensitised workers. Data on workers who underwent specific inhalation challenges with occupational sensitisers (117 exposed to HMW agents and 130 to LMW agents) were collected from their medical charts. Maximum falls in forced expiratory volume in one second (FEV(1)) were of similar magnitude for both types of agents. Compared with HMW agents, LMW agents induced more frequently late or dual responses and higher increases in airway responsiveness. After exposure to HMW agents, there was a mean+/-sd reduction in doubling concentrations of methacholine of 0.5+/-1.7 for early responses, compared with 2.8+/-1.2 and 1.4+/-2.0 for late and dual responses, respectively. Isolated early responses were more frequently found in females, smokers, workers with a higher % predicted FEV(1) and higher provocation concentration causing a 20% fall in FEV(1), and in those with longer asthma duration. Workers' characteristics, as well...Continue Reading

Citations

Apr 3, 2012·Current Allergy and Asthma Reports·Edgardo J JaresR Maximiliano Gómez
May 2, 2012·Journal of Allergy·J A PralongM Labrecque
Nov 26, 2011·Chest·Philippe PrinceLouis-Philippe Boulet
Jun 16, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A V Wisnewski, M Jones
Feb 19, 2013·Respiratory Medicine·Vinciane D'AlpaosJacques Jamart
Aug 16, 2016·Current Allergy and Asthma Reports·Javier Dominguez-OrtegaSantiago Quirce
Nov 8, 2016·Archivos de bronconeumología·Angelica LealXavier Muñoz
Mar 9, 2017·Occupational and Environmental Medicine·Chunshao HuXavier Munoz
Oct 16, 2018·Current Opinion in Pulmonary Medicine·Santiago Quirce, Joaquín Sastre
Jun 30, 2018·Allergy·Olivier VandenplasUNKNOWN European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) investigators
Nov 20, 2019·Allergy, Asthma & Immunology Research·Agnieszka Lipińska-OjrzanowskaJolanta Walusiak-Skorupa
Jul 1, 2020·International Journal of Environmental Research and Public Health·Angelica I TiotiuDenislava Nedeva
Jul 14, 2012·Expert Review of Respiratory Medicine·Beth E Davis, Donald W Cockcroft
Jul 7, 2020·International Journal of Environmental Research and Public Health·Piero MaestrelliPiera Boschetto
Jun 16, 2021·Journal of Occupational Health·Yasuo MorimotoYangho Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

© 2021 Meta ULC. All rights reserved