PMID: 8967907Dec 1, 1996Paper

Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators

Nucleic Acids Research
P Schjerling, S Holmberg

Abstract

The C6 zinc cluster family of fungal regulatory proteins shares as DNA-binding motif the C6 zinc cluster, also known as the Zn(II)2Cys6 binuclear cluster. This family includes transcriptional activators like Gal4p, Leu3p, Hap1p, Put3p and Cha4p from Saccharomyces cerevisiae, qutA and amdR from Aspergillus, nit4 from Neurospora and Ntf1 from Schizosaccharomyces pombe. Seventy-nine proteins were retrieved from databases by homology to the C6 zinc cluster. All were fungal and 56 were found in the entire genome sequence of S.cerevisiae. Sequence analysis suggests that 60 of the 79 proteins possess one or more coiled-coil dimerization regions succeeding the C6 zinc cluster. Previous comparisons of Gal4p and seven other C6 zinc cluster proteins identified an additional region with weak homology. This region, designated the middle homology region (MHR), was shown to be present in 50 of the 79 proteins. Although reported mutation and deletion analyses suggest a role of MHR in regulation of protein activity, no function has yet been assigned specifically to this region. We find that the family of MHR sequences is confined to C6 zinc cluster proteins and hypothesize that one MHR function is to assist the C6 zinc cluster in DNA target dis...Continue Reading

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Citations

Nov 18, 2008·Molecular Genetics and Genomics : MGG·Ajay K PandeyMaria R Davis
Oct 11, 2005·FEMS Yeast Research·Beatrice RossiEnrico Berardi
Aug 8, 2002·FEMS Microbiology Reviews·José M Siverio
Jun 26, 2002·Fungal Genetics and Biology : FG & B·Sandra MasloffUlrich Kück
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Robert A MoxleySuchareeta Mitra
Sep 26, 1997·Nature Structural Biology·J W Schwabe, D Rhodes
Sep 26, 1997·Nature Structural Biology·K J WaltersG Wagner
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Philipp WiemannNancy P Keller
May 8, 2007·Bioinformatics·Edward WijayaWing-Kin Sung
Mar 29, 2000·Nucleic Acids Research·J van HeldenJ Collado-Vides
May 23, 2001·Nucleic Acids Research·B AkacheB Turcotte
May 17, 2011·Nucleic Acids Research·Sylvain BrohéeJacques van Helden
Aug 29, 2007·Molecular Plant-microbe Interactions : MPMI·Fernando Calero-NietoConcepcion Hera
Feb 12, 2013·Eukaryotic Cell·Jude BeaudoinSimon Labbé
Dec 12, 2012·Eukaryotic Cell·Helen A FosterThomas Höfken

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