Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans

PloS One
Sameer D PantMerete Fredholm

Abstract

The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context of obesity and metabolic diseases because other widely used models (e.g. mice) do not completely recapitulate key pathophysiological features associated with these diseases in humans. Therefore, we established a F2 pig resource population (n = 564) designed to elucidate the genetics underlying obesity and metabolic phenotypes. Segregation of obesity traits was ensured by using breeds highly divergent with respect to obesity traits in the parental generation. Several obesity and metabolic phenotypes were recorded (n = 35) from birth to slaughter (242 ± 48 days), including body composition determined at about two months of age (63 ± 10 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined linkage disequilibrium-linkage analysis was used to identify genome-wide significant associations for collected phenotypes. We identified 229 QTLs which associated with adiposity- and metabolic phenotypes at genome-wide significant levels. Subsequently comparative analyses were performed to identify the ext...Continue Reading

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Citations

Sep 9, 2015·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Thea KristensenSusanna Cirera
Jun 1, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Susanna CireraKerstin Skovgaard
Sep 16, 2017·Molecular Genetics and Genomics : MGG·Caroline M Junker MentzelMerete Fredholm
Jul 31, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Lisheng ZhouJunwu Ma
Sep 19, 2020·Plant Methods·Mathieu DeblieckDragan Perovic

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Software Mentioned

AnimalQTLdb
liftOver
Sscrofa
LDLA
UCSC Genome Browser
Sccrofa
ASReml

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