Comparative analyses of the 9 glycoprotein genes found in wild-type and vaccine strains of varicella-zoster virus

The Journal of Infectious Diseases
Johnathan StorlieCharles Grose

Abstract

The complete DNA sequences of wild-type and vaccine strains of varicella-zoster virus have been published and listed in GenBank. In this comparative genomic analysis, the sequences of the 9 glycoprotein open reading frames (ORFs) were compared. They included gE (ORF68), gI (ORF 67), gC (ORF14), gH (ORF37), gL (ORF60), gB (ORF31), gK (ORF5), gM (ORF50), and gN (ORF8 or ORF9A). After realignment on the basis of newer data, the corrected gB sequence was lengthened to include 931 residues. The data showed that there were glycoprotein polymorphisms that differentiated North American/European strains from Japanese strains-for example, an additional ATG codon in the gL of all Oka strains. Also, there were a small number of coding single-nucleotide polymorphisms present only in glycoproteins of vaccine strains. Because these changes were highly conserved, the structure of the glycoprotein was unlikely to be altered.

References

Nov 1, 1990·Journal of Clinical Microbiology·B ForghaniN J Schmidt
Sep 1, 1986·The Journal of General Virology·A J Davison, J E Scott
Jan 1, 1996·Annual Review of Microbiology·A M Arvin, A A Gershon
Oct 22, 2002·Journal of Virology·Yasuyuki GomiKoichi Yamanishi
Mar 5, 2004·Expert Opinion on Biological Therapy·Michiaki Takahashi
Feb 3, 2005·Seminars in Pediatric Infectious Diseases·Sophie Hambleton, Anne A Gershon
May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Charles Grose
Aug 1, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Silvia NatoliFrancesca Leonardis
Aug 15, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Benita Zweygberg WirgartCharles Grose

❮ Previous
Next ❯

Citations

Sep 13, 2008·Journal of Virology·Sueli L TillieuxVentzislav Vassilev
Apr 13, 2010·The Journal of Infection·So Hee KimEun Hwa Choi
Nov 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vincent T ChowCharles Grose
Mar 16, 2017·Journal of Medical Virology·Satish K MehtaDuane L Pierson
Sep 27, 2014·The Journal of Pathology·Werner Jd Ouwendijk, Georges Mgm Verjans
Jun 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cindy GutzeitGünther Schönrich
Jul 1, 2018·Viruses·Daniel P DepledgeWerner J D Ouwendijk
May 12, 2016·Experimental and Therapeutic Medicine·Lidao BaoHaijun Lv

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.