Comparative analysis of abdominal fluid cytokine levels in ovarian hyperstimulation syndrome (OHSS)

Journal of Ovarian Research
Balint FarkasMiklos Koppan

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a rare, yet severe, iatrogenic complication of ovulation induction therapy during assisted reproductive procedures. Our group previously detected atypical cells in the ascitic fluid of OHSS patients, although no malignancy developed during follow up. Here, the aim was to perform a comparative analysis of the cytokines present in the abdominal fluid of patients affected by OHSS versus patients with advanced ovarian cancer, a benign adnexal mass, or ovarian endometriosis. This prospective, non-randomized study was conducted at the Clinical Center of the University of Pecs Department of Obstetrics and Gynecology/Reproductive Center between October 2016 and March 2018. Abdominal fluid samples were obtained from 76 patients and subjected to Luminex analysis. The samples were collected from patients with OHSS (OHSS; n = 16), advanced ovarian cancer (OC; n = 22), a benign adnexal mass (BAM; n = 21), or ovarian endometriosis (EM; n = 17). Data were subjected to the non-parametric Kruskal-Wallis test and Spearman's rank correlation coefficient to identify statistical differences between the four study groups. Leukocytosis and hemoconcentration were detected in the peripheral blood of OHSS pati...Continue Reading

References

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Citations

Oct 17, 2020·Reproductive Sciences·Aleksei Petrovich PetrenkoElena Sergeevna Nesnova

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Methods Mentioned

BETA
lavage
Assay

Software Mentioned

SPSS Statistic

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