Comparative analysis of cellular immune responses and cytokine levels in sheep experimentally infected with bluetongue virus serotype 1 and 8

Veterinary Microbiology
P J Sánchez-CordónM Pedrera

Abstract

Protective immunity in sheep with bluetongue virus (BTV) infection as well as the role of BTV-induced cytokines during immune response remains unclear. Understanding the basis immunological mechanisms in sheep experimentally infected with serotypes 1 and 8 (BTV-1 and -8) was the aim of this study. A time-course study was carried out in order to evaluate cell-mediated immune response and serum concentrations of cytokines (IL-1β, TNFα, IL-12, IFNγ, IL-4 and IL-10) with inflammatory and immunological functions. Depletion of T cell subsets (mainly CD4(+), γδ and CD25(+)) together with the absence of cytokines (IFNγ and IL-12) involved in the regulation of cell-mediated antiviral immunity at the first stage of the disease suggested that both BTV-1 and BTV-8 might impair host's capability against primary infections which would favor viral replication and spreading. However, cellular immune response and cytokines elicited an immune response in sheep that efficiently reduced viremia in the final stage of the experiment. Recovery of T cell subsets (CD4(+) and CD25(+)) together with a significant increase of CD8(+) T lymphocytes in both infected groups were observed in parallel with the decrease of viremia. Additionally, the recovery of ...Continue Reading

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Citations

Jan 10, 2017·Frontiers in Immunology·Morgan C HunterCornelia Halin
Jul 1, 2017·Veterinary Research·José-Manuel RojasNoemí Sevilla
May 1, 2021·International Journal of Molecular Sciences·Louise A Johnson
Jun 26, 2021·Frontiers in Microbiology·José Manuel RojasNoemí Sevilla
Aug 29, 2021·Viruses·Daniel Rodríguez-MartínNoemí Sevilla

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