Oct 29, 2018

Comparative analysis of cellular immune responses in conventional and SPF Baboons (Papio spp.)

BioRxiv : the Preprint Server for Biology
Elizabeth R MagdenPramod N Nehete

Abstract

Baboons (papio spp.) have served as a successful model of human disease such as cardiac and respiratory, infectious, diabetes, genetics, immunology, aging, and xenotransplantation. The development of an immunologically defined specific-pathogen free (SPF) baboon model has further advanced research, especially with studies involving the immune system and immunosuppression. In this study, we compare normal immunological changes of peripheral blood mononuclear cell (PBMC) subsets, and their function in age-matched conventional and SPF baboons. Our results demonstrate that both groups have comparable numbers of different lymphocyte subsets, but there are phenotypic differences in central and effector memory T cells subsets that are more pronounced in the CD4+ T cells. Despite equal proportions of CD3+ T cells among the conventional and SPF baboon groups, PBMC show higher proliferative responses to mitogens PHA and PWM and higher IFN-γ producing cells to Con A and PWM in the conventional group. Plasma levels of the inflammatory cytokine TNF-α were significantly higher in SPF baboons. Exposure of PBMC from conventional baboons to various Toll like ligands (TLR ligands) TLR-3, TLR-4 and TLR-8 show higher IFN-γ producing cells while PB...Continue Reading

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Mentioned in this Paper

Study
Immune System
Research
T-Lymphocyte
Decreased Immunologic Activity [PE]
TLR6
TLR4 gene
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Pathogenic Organism

About this Paper

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